Publications

Cover of Cell journal

Yu M, Ma, L, Yuan Y, Ye X, Montagne, A, He J, Ho T, Wu Y, Zhao Z, Maria NS, Jacobs R, Urata M, Wang H, Zlokovic BZ, Chen JF, Chai Y. (2021) Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis. Cell 184(1): P243-P256.

Cover of Nature Cell Biology

Zhao H, Feng J, Ho TV, Grimes WC, Urata MM, and Chai Y. 2015. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nature Cell Biology 17, 386-396.

Cover of Development journal April 2000

Chai Y, Jiang X, Ito Y, Bringas, Jr. P, Han J, Rowitch D, Soriano P, McMahon A, and Sucov H. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127, 1671-1679.

Cover of Cell Stem Cell

Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, and Chai Y. 2014. Secretion of Shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 14, 160-173.

Cover of Developmental Cell

Xu X, Han J, Ito Y, Bringas P, Deng CX, and Chai Y. 2008. Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Developmental Cell 15, 322-329.

Cover of Human Molecular Genetics

Iwata J, Suzuki A, Pelikan R, Ho TV, Sanchez-Lara PA, and Chai Y. 2014. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Human Molecular Genetics 23, 192-193.

Cover of Development journal

Liu Y, Feng J, Li J, Zhao H, Ho TV, and Chai Y. 2015. An Nfic-Hedgehog signaling cascade regulates tooth root development. Development 142, 3374-3382.

Cover of The Journal of Clinical Investigation

Iwata J, Hacia J, Suzuki A, Sanchez-Lara PA, Urata MM, and Chai Y. 2012. Modulation of non-canonical TGF-beta signaling prevents cleft palate in Tgfbr2 mutant mice. Journal of Clinical Investigation 122, 873-885.

Cover of Development journal November 2015

Parada C, Dong H, Grimaldi A, Sarrion P, Park SS, Pelikan R, Sanchez PA, and Chai Y. 2015. Disruption of ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development 142, 3734-3745.

Cover of Development journal February 2014

Iwata J, Suzuki A, Yokota T, Ho TV, Urata MM, Sanchez PA, and Chai Y. 2014. TGF-beta-mediated WNT signaling regulates epithelial-mesenchymal interactions to control muscle development in the soft palate. Development 141, 909-917.

Cover of Development journal May 2012

Han D, Zhao H, Parada C, Hacia J, Bringas P, and Chai Y. 2012. TGF-beta-Smad4-FGF6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development 139, 1640-1650.

Cover of Developmental Cell April 2015

Li J, Feng J, Liu Y, Ho TV, Grimes WC, Ho H, Park SS, Wang S, and Chai Y. 2015. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Developmental Cell 33, 125-135.

Cover of Developmental Biology 2015

Ho TV, Iwata J, Ho HA, Grimes WC, Park SS, Sanchez-Lara PA, and Chai Y. 2015. Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Developmental Biology 400, 180-190.

Cover of Cell Reports

Chen S, Jing J, Yuan Y, Feng J, Han X, Wen Q, Ho TV, Lee C, Chai Y.(2020) Runx2+ niche cells maintain mesenchymal tissue homeostasis through IGF signaling. Cell Reports 32(6): 108007. doi: 10.1016/j.celrep.2020.108007

Cover of Journal of Dental Research
Cover of Science Advances

Yuan Y, Loh YE, Han X, Feng J, Ho T, He J, Jing J, Groff K, Wu A, Chai Y. (2020) Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Science Advances 6(51): eabb0119.

Cover of Development journal

Samuels BD ... Chai Y. (2020) FaceBase 3: Analytical Tools and FAIR Resources for Craniofacial and Dental Research. Development 147(18): dev191213.

  1. Nguyen VX, Yoshida M, Samuels BD, Giannobile WV, Healy KE, Jamieson MW, Lane NE, Longaker MT, Mooney D, Sfeir CS, Sinha UK, Wagner WR, Lotz JC, Kohn DH, Chai Y. Dental, Oral and Craniofacial Tissue Regeneration Consortium (DOCTRC): An Infrastructure for Accelerating Regenerative Therapies from Discovery to Clinical Impact. Journal of Clinical and Translational Science. Accepted.
  2. Zhang M, Feng J, Guo T, Meng L, Pei F, Gao L, Yang Y, Ho TV, Chai Y. Canonical BAF chromatin remodeling complex specifies stem cell fate via cell-type-specific co-factor recruitment. Nature Communications. Accepted.
  3. Shen KA, Lee JJ, Cheng SY, Jackert EP, Tang L, Kwon D, Kokot N, Sinha U, Chai Y, Eoh H, Han AY. (2025) Enhanced glycolysis and nicotinamide metabolism in HPV-positive head and neck cancer. Sci Rep. 2025 Nov 28;15(1):42714. doi: 10.1038/s41598-025-26690-x. PMID: 41315496; PMCID: PMC12663544.
  4. Wenger TA, Wong S, Cheng SY, Tang L, Kwon D, Kokot N, Chai Y, Sinha U, Han AY. (2025) Incidence and Outcomes of Head and Neck Cancer in Patients With Schizophrenia. OTO Open. 2025 Sep 19;9(3):e70164. doi: 10.1002/oto2.70164. PMID: 40978803; PMCID: PMC12447352.
  5. Meng L, Feng J, Guo T, Zhang M, Cha S, Chen P, Ziaei H, Harouni A, Ho TV, Chai Y. (2025) Piezo2+ mechanosensory neurons orchestrate postnatal development through mechano-chemo-transduction of PDGFA signaling. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2504103122. doi: 10.1073/pnas.2504103122. Epub 2025 Jul 8. PMID: 40627386.
  6. Feng J, Janečková E, Guo T, Ziaei H, Zhang M, Geng JJ, Cha S, Araujo-Villalba A, Liu M, Ho TV, Chai Y. (2025) High-resolution spatial transcriptomics and cell lineage analysis reveal spatiotemporal cell fate determination during craniofacial development. Nat Commun. 2025 May 12;16(1):4396. doi: 10.1038/s41467-025-59206-2. PMID: 40355462.
  7. Buchanan C, Chen S, Yuan Y, Guo T, Feng J, Zhang M, Carey G, Howard I, Sanchez J, Ho TV, Chai Y. (2025) Loss of Runx2 in Gli1+ osteogenic progenitors prevents bone loss following ovariectomy. JBMR Plus. 2024 Nov 9;9(1):ziae141. doi: 10.1093/jbmrpl/ziae141. PMID: 39996169; PMCID: PMC11848843.
  8. Pei F, Guo T, Zhang M, Ma L, Jing J, Feng J, Ho TV, Wen Q, Chai Y. (2024) FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development. Bone Res. 2024 Jun 24;12(1):37. doi: 10.1038/s41413-024-00345-5. PMID: 38910207; PMCID: PMC11194271.
  9. Zhang M, Guo T, Pei F, Feng J, Jing J, Xu J, Yamada T, Ho TV, Du J, Sehgal P, Chai Y. (2024) ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling. Nat Commun. 2024 May 30;15(1):4614. doi: 10.1038/s41467-024-48285-2. PMID: 38816354; PMCID: PMC11139927.
  10. Guo T, Pei F, Zhang M, Yamada T, Feng J, Jing J, Ho TV, Chai Y. (2024) Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor. Cell Stem Cell. 2024 Jun 6;31(6):904-920.e6. doi: 10.1016/j.stem.2024.04.011. Epub 2024 May 3. PMID: 38703771; PMCID: PMC11162319.
  11. Pei F, Ma L, Guo T, Zhang M, Jing J, Wen Q, Feng J, Lei J, He J, Janečková E, Ho TV, Chen JF, Chai Y. (2024) Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis. Development. 2024 Jan 15;151(2):dev202043. doi: 10.1242/dev.202043. Epub 2024 Jan 11. PMID: 38108472; PMCID: PMC10820866.
  12. Stanton E, Feng J, Kondra K, Sanchez J, Jimenez C, Brown KS, Skiles ML, Urata MM, Chai Y, Hammoudeh JA. (2023) A Calvarial Defect Model to Investigate the Osteogenic Potential of Umbilical Cord Stem Cells in Bone Regeneration. (2023) Plast Reconstr Surg. 2024 Mar 1;153(3):637-646. doi: 10.1097/PRS.0000000000010754. Epub 2023 May 24. PMID: 37224290.
  13. Zhang M, Feng J, Li Y, Qin PZ, Chai Y. (2023) Generation of tamoxifen-inducible Tfap2b-CreERT2 mice using CRISPR-Cas9. Genesis. 2024 Feb;62(1):e23582. doi: 10.1002/dvg.23582. Epub 2023 Dec 8. PMID: 38069547; PMCID: PMC11021159.
  14. Ma L, Chang Q, Pei F, Liu M, Zhang W, Hong YK, Chai Y, Chen JF. (2023) Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis. Cell Stem Cell. 2023 Nov 2;30(11):1472-1485.e7. doi: 10.1016/j.stem.2023.09.012. Epub 2023 Oct 19. PMID: 37863055; PMCID: PMC10842404.
  15. Janečková E, Feng J, Guo T, Han X, Ghobadi A, Araujo-Villalba A, Rahman MS, Ziaei H, Ho TV, Pareek S, Alvarez J, Chai Y. (2023) Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis. Development. 2023 Mar 1;150(5):dev201189. doi: 10.1242/dev.201189. Epub 2023 Mar 9. PMID: 36825984; PMCID: PMC10108707.
  16. Black N, Chai Y. (2023) Current Understanding of the Regulatory Mechanism of Tooth Root Development and Future Perspectives. J Calif Dent Assoc. 2023;51(1):2194560. doi: 10.1080/19424396.2023.2194560. Epub 2023 Mar 30. PMID: 37193003; PMCID: PMC10168653.
  17. Pei F, Ma L, Jing J, Feng J, Yuan Y, Guo T, Han X, Ho TV, Lei J, He J, Zhang M, Chen JF, Chai Y. (2023) Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. Nat Commun. 2023 Jan 20;14(1):344. doi: 10.1038/s41467-023-35977-4. PMID: 36670126; PMCID: PMC9859800.
  18. Jing J, Zhang M, Guo T, Pei F, Yang Y, and Chai Y. (2022) Rodent incisor as a model to study mesenchymal stem cells in tissue homeostasis and repair. Front. Dent. Med, 30 November 2022, Volume 3 – 2022. https://doi.org/10.3389/fdmed.2022.1068494.
  19. Feng J, Han X, Yuan Y, Cho CK, Janečková E, Guo T, Pareek S, Rahman MS, Zheng B, Bi J, Jing J, Zhang M, Xu J, Ho TV, Chai Y. (2022) TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. eLife. 2022 Dec 21;11:e80405. doi: 10.7554/eLife.80405. PMID: 36542062; PMCID: PMC9771365.
  20. Stanton E, Sheridan S, Urata M, Chai Y. (2022) From Bedside to Bench and Back: Advancing Our Understanding of the Pathophysiology of Cleft Palate and Implications for the Future. Cleft Palate Craniofac J. 2024 May;61(5):759-773. doi: 10.1177/10556656221142098. Epub 2022 Dec 1. PMID: 36457208.
  21. Jing J, Feng J, Yuan Y, Guo T, Lei J, Pei F, Ho TV, Chai Y. (2022) Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803. doi: 10.1038/s41467-022-32490-y. PMID: 35974052; PMCID: PMC9381504.
  22. Gu R, Zhang S, Saha SK, Ji Y, Reynolds K, McMahon M, Sun B, Islam M, Trainor PA, Chen Y, Xu Y, Chai Y, Burkart-Waco D, Zhou CJ. (2022) Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts. Development. 2022 Jul 15;149(14):dev200533. doi: 10.1242/dev.200533. Epub 2022 Jul 22. PMID: 35781558; PMCID: PMC9382898.
  23. Schuler RE, Bugacov A, Hacia JG, Ho TV, Iwata J, Pearlman L, Samuels BD, Williams C, Zhao Z, Kesselman C, Chai Y. (2022) FaceBase: A Community-Driven Hub for Data-Intensive Research. J Dent Res. 2022 Oct;101(11):1289-1298. doi: 10.1177/00220345221107905. Epub 2022 Jul 31. PMID: 35912790; PMCID: PMC9516628.
  24. Stanton E, Urata M, Chen JF, Chai Y. (2022) The clinical manifestations, molecular mechanisms and treatment of craniosynostosis. Dis Model Mech. 2022 Apr 1;15(4):dmm049390. doi: 10.1242/dmm.049390. Epub 2022 Apr 22. PMID: 35451466; PMCID: PMC9044212.
  25. Guo T, Han X, He J, Feng J, Jing J, Janečková E, Lei J, Ho TV, Xu J, Chai Y. (2022) KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. eLife. 2022 Feb 25;11:e74595. doi: 10.7554/eLife.74595. PMID: 35212626; PMCID: PMC9007587.
  26. Ting MC, Farmer DT, Teng CS, He J, Chai Y, Crump JG, Maxson RE. (2022) Embryonic requirements for Tcf12 in the development of the mouse coronal suture. Development. 2022 Jan 1;149(1):dev199575. doi: 10.1242/dev.199575. Epub 2022 Jan 4. PMID: 34878091; PMCID: PMC8783042.
  27. Lei J, Chen S, Jing J, Guo T, Feng J, Ho TV, Chai Y. (2022) Inhibiting Hh Signaling in Gli1+ Osteogenic Progenitors Alleviates TMJOA. J Dent Res. 2022 Jun;101(6):664-674. doi: 10.1177/00220345211059079. Epub 2022 Jan 20. PMID: 35045740; PMCID: PMC9124909.
  28. Ma L, Wang J, Ge J, Wang Y, Zhang W, Du Y, Luo J, Li Y, Wang F, Fan G, Chen R, Yao B, Zhao Z, Guo ML, Kim WK, Chai Y, Chen JF. (2021) Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus. EMBO Rep. 2021 Aug 4;22(8):e51978. doi: 10.15252/embr.202051978. Epub 2021 Jul 7. PMID: 34232545; PMCID: PMC8344882.
  29. Du J, Jing J, Chen S, Yuan Y, Feng J, Ho TV, Sehgal P, Xu J, Jiang X, Chai Y. (2021) Arid1a regulates cell cycle exit of transit-amplifying cells by inhibiting the Aurka-Cdk1 axis in mouse incisor. Development. 2021 Apr 15;148(8):dev198838. doi: 10.1242/dev.198838. Epub 2021 Apr 16. PMID: 33766930; PMCID: PMC8077510.
  30. Du J, Jing J, Yuan Y, Feng J, Han X, Chen S, Li X, Peng W, Xu J, Ho TV, Jiang X, Chai Y. (2021) Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors. Cell Rep. 2021 Apr 6;35(1):108964. doi: 10.1016/j.celrep.2021.108964. PMID: 33826897; PMCID: PMC8132592.
  31. Johnson ZM, Yuan Y, Li X, Jashashvili T, Jamieson M, Urata M, Chen Y, Chai Y. (2021) Mesenchymal stem cells and three-dimensional-osteoconductive scaffold regenerate calvarial bone in critical size defects in swine. Stem Cells Transl Med. 2021 Aug;10(8):1170-1183. doi: 10.1002/sctm.20-0534. Epub 2021 Apr 1. PMID: 33794062; PMCID: PMC8284781.
  32. Han X, Feng J, Guo T, Loh YE, Yuan Y, Ho TV, Cho CK, Li J, Jing J, Janečková E, He J, Pei F, Bi J, Song B, Chai Y. (2021) Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. eLife. 2021 Jan 22;10:e62387. doi: 10.7554/eLife.62387. PMID: 33482080; PMCID: PMC7826157.
  33. He J, Jing J, Feng J, Han X, Yuan Y, Guo T, Pei F, Ma Y, Cho C, Ho TV, Chai Y. (2021) Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning. PLoS Genet. 2021 Feb 17;17(2):e1009320. doi: 10.1371/journal.pgen.1009320. PMID: 33596195; PMCID: PMC7920342.
  34. Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. (2021) Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis. Cell. 2021 Jan 7;184(1):243-256.e18. doi: 10.1016/j.cell.2020.11.037. PMID: 33417861; PMCID: PMC7891303.
  35. Jing J, Feng J, Li J, Zhao H, Ho TV, He J, Yuan Y, Guo T, Du J, Urata M, Sharpe P, Chai Y. (2021) Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis. eLife. 2021 Jan 22;10:e59459. doi: 10.7554/eLife.59459. PMID: 33480845; PMCID: PMC7822593.
  36. Ma Y, Jing J, Feng J, Yuan Y, Wen Q, Han X, He J, Chen S, Ho TV, Chai Y. (2021) Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development. Development. 2021 Jan 21;148(2):dev196360. doi: 10.1242/dev.196360. PMID: 33323370; PMCID: PMC7847279.
  37. Yuan Y, Loh YE, Han X, Feng J, Ho TV, He J, Jing J, Groff K, Wu A, Chai Y. (2020) Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Sci Adv. 2020 Dec 16;6(51):eabb0119. doi: 10.1126/sciadv.abb0119. PMID: 33328221; PMCID: PMC7744069.
  38. Men Y, Wang Y, Yi Y, Jing D, Luo W, Shen B, Stenberg W, Chai Y, Ge WP, Feng JQ, Zhao H. (2020) Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force. Dev Cell. 2020 Sep 14;54(5):639-654.e6. doi: 10.1016/j.devcel.2020.06.006. Epub 2020 Jul 10. PMID: 32652075.
  39. Li X, Shan W, Yang Y, Joralmon D, Zhu Y, Chen Y, Yuan Y, Xu H, Rong J, Dai R, Nian Q, Chai Y, Chen Y. (2020). Limpet Tooth‐Inspired Painless Microneedles Fabricated by Magnetic Field‐Assisted 3D Printing. Advanced Functional Materials. 31. 10.1002/adfm.202003725.
  40. Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. (2020) FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research. Development. 2020 Sep 21;147(18):dev191213. doi: 10.1242/dev.191213. PMID: 32958507; PMCID: PMC7522026.
  41. Chen S, Jing J, Yuan Y, Feng J, Han X, Wen Q, Ho TV, Lee C, Chai Y. (2020) Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling. Cell Rep. 2020 Aug 11;32(6):108007. doi: 10.1016/j.celrep.2020.108007. PMID: 32783935; PMCID: PMC7461627.
  42. Wen Q, Jing J, Han X, Feng J, Yuan Y, Ma Y, Chen S, Ho TV, Chai Y. (2020) Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM. J Bone Miner Res. 2020 Nov;35(11):2252-2264. doi: 10.1002/jbmr.4120. Epub 2020 Aug 3. PMID: 32569388; PMCID: PMC7689689.
  43. Jackson-Weaver O, Ungvijanpunya N, Yuan Y, Qian J, Gou Y, Wu J, Shen H, Chen Y, Li M, Richard S, Chai Y, Sucov HM, Xu J. (2020) PRMT1-p53 Pathway Controls Epicardial EMT and Invasion. Cell Rep. 2020 Jun 9;31(10):107739. doi: 10.1016/j.celrep.2020.107739. PMID: 32521264; PMCID: PMC7425665.
  44. Zhang W, Ma L, Yang M, Shao Q, Xu J, Lu Z, Zhao Z, Chen R, Chai Y, Chen JF. (2020) Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes Dev. 2020 Apr 1;34(7-8):580-597. doi: 10.1101/gad.332494.119. Epub 2020 Feb 27. PMID: 32115408; PMCID: PMC7111266.
  45. Zhang W, Ma L, Yang M, Shao Q, Xu J, Lu Z, Zhao Z, Chen R, Chai Y, Chen JF. (2020) Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes Dev. 2020 Apr 1;34(7-8):580-597. doi: 10.1101/gad.332494.119. Epub 2020 Feb 27. PMID: 32115408; PMCID: PMC7111266.
  46. Zhang C, Lin J, Nguyen NT, Guo Y, Xu C, Seo C, Villafana E, Jimenez H, Chai Y, Guan R, Liu H. (2019) Antimicrobial Bioresorbable Mg-Zn-Ca Alloy for Bone Repair in a Comparison Study with Mg-Zn-Sr Alloy and Pure Mg. ACS Biomater Sci Eng. 2020 Jan 13;6(1):517-538. doi: 10.1021/acsbiomaterials.9b00903. Epub 2019 Dec 31. PMID: 33463195; PMCID: PMC8218913.
  47. Janečková E, Feng J, Li J, Rodriguez G, Chai Y. (2019) Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development. PLoS One. 2019 Oct 15;14(10):e0223879. doi: 10.1371/journal.pone.0223879. PMID: 31613912; PMCID: PMC6793855.
  48. Jing J, Feng J, Li J, Han X, He J, Ho TV, Du J, Zhou X, Urata M, Chai Y. (2019) Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars. eLife. 2019 Jul 1;8:e46426. doi: 10.7554/eLife.46426. PMID: 31259687; PMCID: PMC6602580.
  49. Shi C, Yuan Y, Guo Y, Jing J, Ho TV, Han X, Li J, Feng J, Chai Y. (2019) BMP Signaling in Regulating Mesenchymal Stem Cells in Incisor Homeostasis. J Dent Res. 2019 Jul;98(8):904-911. doi: 10.1177/0022034519850812. Epub 2019 May 28. PMID: 31136721; PMCID: PMC6616121.
  50. Li J, Rodriguez G, Han X, Janečková E, Kahng S, Song B, Chai Y. (2019) Regulatory Mechanisms of Soft Palate Development and Malformations. J Dent Res. 2019 Aug;98(9):959-967. doi: 10.1177/0022034519851786. Epub 2019 May 31. PMID: 31150594; PMCID: PMC6651766.
  51. Yuan Y, Chai Y. (2019) Regulatory mechanisms of jaw bone and tooth development. Curr Top Dev Biol. 2019;133:91-118. doi: 10.1016/bs.ctdb.2018.12.013. Epub 2019 Feb 11. PMID: 30902260; PMCID: PMC6986348.
  52. Kousa YA, Zhu H, Fakhouri WD, Lei Y, Kinoshita A, Roushangar RR, Patel NK, Agopian AJ, Yang W, Leslie EJ, Busch TD, Mansour TA, Li X, Smith AL, Li EB, Sharma DB, Williams TJ, Chai Y, Amendt BA, Liao EC, Mitchell LE, Bassuk AG, Gregory S, Ashley-Koch A, Shaw GM, Finnell RH, Schutte BC. (2019) The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. Hum Mol Genet. 2019 May 15;28(10):1726-1737. doi: 10.1093/hmg/ddz010. PMID: 30689861; PMCID: PMC6494790.
  53. Guo Y, Yuan Y, Wu L, Ho TV, Jing J, Sugii H, Li J, Han X, Feng J, Guo C, Chai Y. (2018) BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair. Bone Res. 2018 Oct 17;6:30. doi: 10.1038/s41413-018-0031-x. PMID: 30345151; PMCID: PMC6193039.
  54. Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y. (2018) Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 Sep 1;441(1):191-203. doi: 10.1016/j.ydbio.2018.07.003. Epub 2018 Jul 5. PMID: 29981310; PMCID: PMC6152919.
  55. Bobarnac Dogaru GL, Juneja SC, Shokrani A, Hui RY, Chai Y, Pepper JP. (2018) The role of Hedgehog-responsive fibroblasts in facial nerve regeneration. Exp Neurol. 2018 May;303:72-79. doi: 10.1016/j.expneurol.2018.01.008. Epub 2018 Jan 11. PMID: 29337143.
  56. Zhang T, Wu J, Ungvijanpunya N, Jackson-Weaver O, Gou Y, Feng J, Ho TV, Shen Y, Liu J, Richard S, Jin J, Hajishengallis G, Chai Y, Xu J. (2018) Smad6 Methylation Represses NFκB Activation and Periodontal Inflammation. J Dent Res. 2018 Jul;97(7):810-819. doi: 10.1177/0022034518755688. Epub 2018 Feb 8. PMID: 29420098; PMCID: PMC6728583.
  57. Giannobile WV, Chai Y, Chen Y, Healy KE, Klein O, Lane N, Longaker MT, Lotz JC, Mooney DJ, Sfeir CS, Urata M, Wagner WR, Wu BM, Kohn DH. (2018) Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care. J Dent Res. 2018 Apr;97(4):361-363. doi: 10.1177/0022034518761346. PMID: 29557734; PMCID: PMC5863875.
  58. Gou Y, Li J, Jackson-Weaver O, Wu J, Zhang T, Gupta R, Cho I, Ho TV, Chen Y, Li M, Richard S, Wang J, Chai Y, Xu J. (2018) Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis. J Dent Res. 2018 Dec;97(13):1510-1518. doi: 10.1177/0022034518785164. Epub 2018 Jul 9. PMID: 29986157; PMCID: PMC6728548.
  59. An Z, Akily B, Sabalic M, Zong G, Chai Y, Sharpe PT. (2018) Regulation of Mesenchymal Stem to Transit-Amplifying Cell Transition in the Continuously Growing Mouse Incisor. Cell Rep. 2018 Jun 5;23(10):3102-3111. doi: 10.1016/j.celrep.2018.05.001. PMID: 29874594; PMCID: PMC6383149.
  60. Sugii H, Grimaldi A, Li J, Parada C, Vu-Ho T, Feng J, Jing J, Yuan Y, Guo Y, Maeda H, Chai Y. (2017) The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development. Development. 2017 Nov 1;144(21):4037-4045. doi: 10.1242/dev.155176. Epub 2017 Oct 5. PMID: 28982687; PMCID: PMC5702075.
  61. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y. (2017) BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017 Jul 15;144(14):2560-2569. doi: 10.1242/dev.150136. Epub 2017 Jun 2. PMID: 28576771; PMCID: PMC5536932.
  62. Tian H, Feng J, Li J, Ho TV, Yuan Y, Liu Y, Brindopke F, Figueiredo JC, Magee W 3rd, Sanchez-Lara PA, Chai Y. (2017) Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Hum Mol Genet. 2017 Mar 1;26(5):860-872. doi: 10.1093/hmg/ddx002. PMID: 28069795; PMCID: PMC6075526.
  63. Li J, Parada C, Chai Y. (2017) Cellular and molecular mechanisms of tooth root development. Development. 2017 Feb 1;144(3):374-384. doi: 10.1242/dev.137216. PMID: 28143844; PMCID: PMC5341797.
  64. Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. (2016) Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Nov 15;143(22):4115-4126. doi: 10.1242/dev.138883. Epub 2016 Sep 22. PMID: 27660324; PMCID: PMC5117215.
  65. Park S, Zhao H, Urata M, Chai Y. (2016) Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury. Stem Cells Dev. 2016 Dec 1;25(23):1801-1807. doi: 10.1089/scd.2016.0211. Epub 2016 Oct 24. PMID: 27762665; PMCID: PMC5124738.
  66. Feng J, Jing J, Sanchez-Lara PA, Bootwalla MS, Buckley J, Wu N, Yan Y, Chai Y. (2016) Generation and characterization of tamoxifen-inducible Pax9-CreER knock-in mice using CrispR/Cas9. Genesis. 2016 Sep;54(9):490-6. doi: 10.1002/dvg.22956. Epub 2016 Jul 26. PMID: 27381449; PMCID: PMC5021577.
  67. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J; FaceBase Consortium; Chai Y. (2016) The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15;143(14):2677-88. doi: 10.1242/dev.135434. Epub 2016 Jun 10. PMID: 27287806; PMCID: PMC4958338.
  68. Burg ML, Chai Y, Yao CA, Magee W 3rd, Figueiredo JC. (2016) Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Front Physiol. 2016 Mar 1;7:67. doi: 10.3389/fphys.2016.00067. PMID: 26973535; PMCID: PMC4771933.
  69. Grimaldi A, Parada C, Chai Y. (2015) A Comprehensive Study of Soft Palate Development in Mice. PLoS One. 2015 Dec 15;10(12):e0145018. doi: 10.1371/journal.pone.0145018. PMID: 26671681; PMCID: PMC4687642.
  70. Parada C, Chai Y. (2015) Mandible and Tongue Development. Curr Top Dev Biol. 2015;115:31-58. doi: 10.1016/bs.ctdb.2015.07.023. Epub 2015 Oct 1. PMID: 26589920; PMCID: PMC4869709.
  71. Parada C, Han D, Grimaldi A, Sarrión P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y. (2015) Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 1;142(21):3734-45. doi: 10.1242/dev.125328. Epub 2015 Sep 22. PMID: 26395480; PMCID: PMC4647211.
  72. Zhao H, Chai Y. (2015) Stem Cells in Teeth and Craniofacial Bones. J Dent Res. 2015 Nov;94(11):1495-501. doi: 10.1177/0022034515603972. Epub 2015 Sep 8. PMID: 26350960; PMCID: PMC4622324.
  73. Liu Y, Feng J, Li J, Zhao H, Ho TV, Chai Y. (2015) An Nfic-hedgehog signaling cascade regulates tooth root development. Development. 2015 Oct 1;142(19):3374-82. doi: 10.1242/dev.127068. Epub 2015 Aug 20. PMID: 26293299; PMCID: PMC4631759.
  74. Li J, Feng J, Liu Y, Ho TV, Grimes W, Ho HA, Park S, Wang S, Chai Y. (2015) BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev Cell. 2015 Apr 20;33(2):125-35. doi: 10.1016/j.devcel.2015.02.021. Epub 2015 Apr 9. PMID: 25865348; PMCID: PMC4406846.
  75. Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. (2015) The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr;17(4):386-96. doi: 10.1038/ncb3139. Epub 2015 Mar 23. PMID: 25799059; PMCID: PMC4380556.
  76. Kim TH, Bae CH, Lee JY, Lee JC, Ko SO, Chai Y, Cho ES. (2015) Temporo-spatial requirement of Smad4 in dentin formation. Biochem Biophys Res Commun. 2015 Apr 17;459(4):706-12. doi: 10.1016/j.bbrc.2015.03.014. Epub 2015 Mar 11. PMID: 25770424.
  77. Ho TV, Iwata J, Ho HA, Grimes WC, Park S, Sanchez-Lara PA, Chai Y. (2015) Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Dev Biol. 2015 Apr 15;400(2):180-90. doi: 10.1016/j.ydbio.2015.02.010. Epub 2015 Feb 23. PMID: 25722190; PMCID: PMC4385433.
  78. Zhong Z, Zhao H, Mayo J, Chai Y. (2015) Different requirements for Wnt signaling in tongue myogenic subpopulations. J Dent Res. 2015 Mar;94(3):421-9. doi: 10.1177/0022034514566030. Epub 2015 Jan 9. PMID: 25576472; PMCID: PMC4336158.
  79. Slavkin HC, Sanchez-Lara PA, Chai Y, Urata M. (2014) A model for interprofessional health care: lessons learned from craniofacial teams. J Calif Dent Assoc. 2014 Sep;42(9):637-44. PMID: 25265730.
  80. Han A, Zhao H, Li J, Pelikan R, Chai Y. (2014) ALK5-mediated transforming growth factor β signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions. Mol Cell Biol. 2014 Aug;34(16):3120-31. doi: 10.1128/MCB.00623-14. Epub 2014 Jun 9. PMID: 24912677; PMCID: PMC4135603.
  81. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. (2014) Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 6;14(2):160-73. doi: 10.1016/j.stem.2013.12.013. Erratum in: Cell Stem Cell. 2018 Jul 05;23(1):147. doi: 10.1016/j.stem.2018.05.023. PMID: 24506883; PMCID: PMC3951379.
  82. Iwata J, Suzuki A, Yokota T, Ho TV, Pelikan R, Urata M, Sanchez-Lara PA, Chai Y. (2014) TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014 Feb;141(4):909-17. doi: 10.1242/dev.103093. PMID: 24496627; PMCID: PMC3912833.
  83. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Chai Y. (2014) Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet. 2014 Jan 1;23(1):182-93. doi: 10.1093/hmg/ddt410. Epub 2013 Aug 23. PMID: 23975680; PMCID: PMC3857953.
  84. Iwata J, Suzuki A, Pelikan RC, Ho TV, Chai Y. (2013) Noncanonical transforming growth factor β (TGFβ) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem. 2013 Oct 11;288(41):29760-70. doi: 10.1074/jbc.M113.493551. Epub 2013 Aug 15. PMID: 23950180; PMCID: PMC3795273.
  85. Xu X, Chen C, Akiyama K, Chai Y, Le AD, Wang Z, Shi S. (2013) Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells. J Dent Res. 2013 Sep;92(9):825-32. doi: 10.1177/0022034513497961. Epub 2013 Jul 18. PMID: 23867762; PMCID: PMC3744273.
  86. Parada C, Li J, Iwata J, Suzuki A, Chai Y. (2013) CTGF mediates Smad-dependent transforming growth factor β signaling to regulate mesenchymal cell proliferation during palate development. Mol Cell Biol. 2013 Sep;33(17):3482-93. doi: 10.1128/MCB.00615-13. Epub 2013 Jul 1. PMID: 23816882; PMCID: PMC3753855.
  87. Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY. (2013) Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells. Circ Res. 2013 Sep 27;113(8):e76-86. doi: 10.1161/CIRCRESAHA.113.301921. Epub 2013 Jul 1. PMID: 23817199; PMCID: PMC3837448.
  88. Mima J, Koshino A, Oka K, Uchida H, Hieda Y, Nohara K, Kogo M, Chai Y, Sakai T. (2013) Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS One. 2013 Apr 17;8(4):e61653. doi: 10.1371/journal.pone.0061653. PMID: 23613893; PMCID: PMC3629100.
  89. Song Z*, Liu C*, Iwata J*, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y. (2013) Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12;288(15):10440-50. doi: 10.1074/jbc.M112.432286. Epub 2013 Mar 4. PMID: 23460641; PMCID: PMC3624426.
  90. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG. (2013) Identification of candidate downstream targets of TGFβ signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013 Apr;114(4):796-807. doi: 10.1002/jcb.24417. PMID: 23060211; PMCID: PMC3777336.
  91. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Urata M, Dixon MJ, Chai Y. (2013) Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013 Mar;140(6):1220-30. doi: 10.1242/dev.089615. Epub 2013 Feb 13. PMID: 23406900; PMCID: PMC3585659.
  92. Huang XF, Chai Y. (2012) Molecular regulatory mechanism of tooth root development. Int J Oral Sci. 2012 Dec;4(4):177-81. doi: 10.1038/ijos.2012.61. Epub 2012 Dec 7. PMID: 23222990; PMCID: PMC3633063.
  93. Parada C, Chai Y. (2012) Roles of BMP signaling pathway in lip and palate development. Front Oral Biol. 2012;16:60-70. doi: 10.1159/000337617. Epub 2012 Jun 25. PMID: 22759670; PMCID: PMC3661199.
  94. Stephens H, Jensen B, Carpiaux W, Sedghizadeh P, Chai Y. (2012) A collaborative approach to advance student research at the University of Southern California. J Calif Dent Assoc. 2012 May;40(5):433-6, 438-9. PMID: 22685951.
  95. Han D, Zhao H, Parada C, Hacia JG, Bringas P Jr, Chai Y. (2012) A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development. 2012 May;139(9):1640-50. doi: 10.1242/dev.076653. Epub 2012 Mar 21. PMID: 22438570; PMCID: PMC3317969.
  96. Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y. (2012) Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar;122(3):873-85. doi: 10.1172/JCI61498. Epub 2012 Feb 13. PMID: 22326956; PMCID: PMC3287237.
  97. Parada C, Han D, Chai Y. (2012) Molecular and cellular regulatory mechanisms of tongue myogenesis. J Dent Res. 2012 Jun;91(6):528-35. doi: 10.1177/0022034511434055. Epub 2012 Jan 4. PMID: 22219210; PMCID: PMC3348065.
  98. Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y. (2011) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor β (TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20;287(4):2353-63. doi: 10.1074/jbc.M111.280974. Epub 2011 Nov 28. PMID: 22123828; PMCID: PMC3268397.
  99. Huang X, Yokota T, Iwata J, Chai Y. (2011) Tgf-beta-mediated FasL-Fas-Caspase pathway is crucial during palatogenesis. J Dent Res. 2011 Aug;90(8):981-7. doi: 10.1177/0022034511408613. Epub 2011 May 18. PMID: 21593251; PMCID: PMC3170164.
  100. Hung Y, Huang X, Chai Y. (2011) Molecular regulatory mechanism of root development. J Calif Dent Assoc. 2011 May;39(5):321-4. PMID: 21721476.
  101. Li J, Huang X, Xu X, Mayo J, Bringas P Jr, Jiang R, Wang S, Chai Y. (2011) SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011 May;138(10):1977-89. doi: 10.1242/dev.061341. Epub 2011 Apr 13. PMID: 21490069; PMCID: PMC3082303.
  102. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. (2011) The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15;355(2):175-82. doi: 10.1016/j.ydbio.2011.02.033. Epub 2011 Mar 31. PMID: 21458441; PMCID: PMC3440302.
  103. Zhao H, Li S, Han D, Kaartinen V, Chai Y. (2011) Alk5-mediated transforming growth factor β signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells. Mol Cell Biol. 2011 May;31(10):2079-89. doi: 10.1128/MCB.01439-10. Epub 2011 Mar 14. PMID: 21402782; PMCID: PMC3133354.
  104. Iwata J, Parada C, Chai Y. (2011) The mechanism of TGF-β signaling during palate development. Oral Dis. 2011 Nov;17(8):733-44. doi: 10.1111/j.1601-0825.2011.01806.x. Epub 2011 Mar 13. PMID: 21395922; PMCID: PMC3329177.
  105. Chung IH, Han J, Iwata J, Chai Y. (2010) Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010 Nov;48(11):645-55. doi: 10.1002/dvg.20671. Epub 2010 Nov 2. PMID: 20824629; PMCID: PMC2995851.
  106. Jinno H, Morozova O, Jones KL, Biernaskie JA, Paris M, Hosokawa R, Rudnicki MA, Chai Y, Rossi F, Marra MA, Miller FD. (2010) Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Stem Cells. 2010 Nov;28(11):2027-40. doi: 10.1002/stem.525. PMID: 20848654; PMCID: PMC3087810.
  107. He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y. (2010) Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 1;347(1):109-21. doi: 10.1016/j.ydbio.2010.08.014. Epub 2010 Aug 19. PMID: 20727875; PMCID: PMC3010875.
  108. Lu L, Wang J, Zhang F, Chai Y, Brand D, Wang X, Horwitz DA, Shi W, Zheng SG. (2010) Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol. 2010 Apr 15;184(8):4295-306. doi: 10.4049/jimmunol.0903418. Epub 2010 Mar 19. PMID: 20304828; PMCID: PMC3087811.
  109. Hosokawa R, Oka K, Yamaza T, Iwata J, Urata M, Xu X, Bringas P Jr, Nonaka K, Chai Y. (2010) TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol. 2010 May 1;341(1):186-95. doi: 10.1016/j.ydbio.2010.02.030. Epub 2010 Feb 26. PMID: 20193675; PMCID: PMC3336866.
  110. Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y. (2010) Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J Biol Chem. 2010 Feb 12;285(7):4975-82. doi: 10.1074/jbc.M109.035105. Epub 2009 Dec 3. PMID: 19959467; PMCID: PMC2836101.
  111. Chai Y. (2010) Towards a molecular understanding of cleft palate. Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Feb 18;42(1):9-13. PMID: 20429146.
  112. Huang X, Xu X, Bringas P Jr, Hung YP, Chai Y. (2010) Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development. J Bone Miner Res. 2010 May;25(5):1167-78. doi: 10.1359/jbmr.091103. PMID: 19888897; PMCID: PMC3153373.
  113. Han J, Mayo J, Xu X, Li J, Bringas P Jr, Maas RL, Rubenstein JL, Chai Y. (2009) Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec;136(24):4225-33. doi: 10.1242/dev.036723. PMID: 19934017; PMCID: PMC2781056.
  114. Huang X, Bringas P Jr, Slavkin HC, Chai Y. (2009) Fate of HERS during tooth root development. Dev Biol. 2009 Oct 1;334(1):22-30. doi: 10.1016/j.ydbio.2009.06.034. Epub 2009 Jul 1. PMID: 19576204; PMCID: PMC2744848.
  115. Oka K, Oka S, Chai Y. (2009) The Role of TGF-β Signaling in Cranial Neural Crest Cells during Mandibular and Tooth Development. J. Oral Biosci. 51(3), 143-150.
  116. Hosokawa R, Deng X, Takamori K, Xu X, Urata M, Bringas P Jr, Chai Y. (2009) Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. J Exp Zool B Mol Dev Evol. 2009 Jun 15;312B(4):343-50. doi: 10.1002/jez.b.21274. PMID: 19235875; PMCID: PMC2896559.
  117. Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixon A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Müller R, Chai Y, Smith E, Bab I, Frenkel B. (2009) Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS One. 2009;4(5):e5438. doi: 10.1371/journal.pone.0005438. Epub 2009 May 4. PMID: 19412553; PMCID: PMC2673053.
  118. Chung IH, Yamaza T, Zhao H, Choung PH, Shi S, Chai Y. (2009) Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. Stem Cells. 2009 Apr;27(4):866-77. doi: 10.1002/stem.2. PMID: 19350689; PMCID: PMC2896558.
  119. Shi S, Chai Y, Slavkin H. (2009) Emerging opportunities for the next generation of dental implants? Dent Today. 2009 Mar;28(3):98-9. PMID: 19323323.
  120. Zhang Z, Lan Y, Chai Y, Jiang R. (2009) Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009 Feb 27;323(5918):1232-4. doi: 10.1126/science.1167418. PMID: 19251632; PMCID: PMC2650836.
  121. Anthwal N, Chai Y, Tucker AS. (2008) The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn. 2008 Jun;237(6):1604-13. doi: 10.1002/dvdy.21567. PMID: 18498113.
  122. Chen H, Zhuang F, Liu YH, Xu B, Del Moral P, Deng W, Chai Y, Kolb M, Gauldie J, Warburton D, Moses HL, Shi W. (2008) TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J. 2008 Aug;32(2):285-95. doi: 10.1183/09031936.00165407. Epub 2008 Mar 5. PMID: 18321928; PMCID: PMC2865234.
  123. De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S. (2008) Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One. 2008 Jan 30;3(1):e1516. doi: 10.1371/journal.pone.0001516. PMID: 18231602; PMCID: PMC2211394.
  124. Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S. (2008) Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008 Aug 22;283(34):23139-49. doi: 10.1074/jbc.M710308200. Epub 2008 Jun 17. PMID: 18559345.
  125. Zhao H, Oka K, Bringas P, Kaartinen V, Chai Y. (2008) TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008 Aug 1;320(1):19-29. doi: 10.1016/j.ydbio.2008.03.045. Epub 2008 Apr 15. PMID: 18572160; PMCID: PMC3629921.
  126. Oka K, Oka S, Hosokawa R, Bringas P Jr, Brockhoff HC 2nd, Nonaka K, Chai Y. (2008) TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol. 2008 Sep 15;321(2):303-9. doi: 10.1016/j.ydbio.2008.03.046. Epub 2008 Apr 15. PMID: 18684439; PMCID: PMC3378386.
  127. Takamori K, Hosokawa R, Xu X, Deng X, Bringas P Jr, Chai Y. (2008) Epithelial fibroblast growth factor receptor 1 regulates enamel formation. J Dent Res. 2008 Mar;87(3):238-43. doi: 10.1177/154405910808700307. PMID: 18296607.
  128. Xing Y, Li C, Hu L, Tiozzo C, Li M, Chai Y, Bellusci S, Anderson S, Minoo P. (2008) Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten. Dev Biol. 2008 Aug 15;320(2):340-50. doi: 10.1016/j.ydbio.2008.04.044. Epub 2008 May 13. PMID: 18602626; PMCID: PMC2597224.
  129. Xu X, Han J, Ito Y, Bringas P Jr, Deng C, Chai Y. (2008) Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Dev Cell. 2008 Aug;15(2):322-9. doi: 10.1016/j.devcel.2008.06.004. PMID: 18694570; PMCID: PMC2610417.
  130. Oka K, Oka S, Sasaki T, Ito Y, Bringas P Jr, Nonaka K, Chai Y. (2007) The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007 Mar 1;303(1):391-404. doi: 10.1016/j.ydbio.2006.11.025. Epub 2006 Nov 21. PMID: 17204263; PMCID: PMC2074881.
  131. Oka S, Oka K, Xu X, Sasaki T, Bringas P Jr, Chai Y. (2007) Cell autonomous requirement for TGF-beta signaling during odontoblast differentiation and dentin matrix formation. Mech Dev. 2007 Jul;124(6):409-15. doi: 10.1016/j.mod.2007.02.003. Epub 2007 Mar 12. PMID: 17449229; PMCID: PMC2704601.
  132. Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y. (2007) Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 1;312(1):435-47. doi: 10.1016/j.ydbio.2007.09.050. Epub 2007 Oct 4. PMID: 17964566; PMCID: PMC2704603.
  133. Pemberton TJ, Li FY, Oka S, Mendoza-Fandino GA, Hsu YH, Bringas P Jr, Chai Y, Snead ML, Mehrian-Shai R, Patel PI. (2007) Identification of novel genes expressed during mouse tooth development by microarray gene expression analysis. Dev Dyn. 2007 Aug;236(8):2245-57. doi: 10.1002/dvdy.21226. PMID: 17626284; PMCID: PMC4457363.
  134. Hosokawa R, Urata M, Han J, Zehnaly A, Bringas P Jr, Nonaka K, Chai Y. (2007) TGF-beta mediated Msx2 expression controls occipital somites-derived caudal region of skull development. Dev Biol. 2007 Oct 1;310(1):140-53. doi: 10.1016/j.ydbio.2007.07.038. Epub 2007 Aug 6. PMID: 17727833; PMCID: PMC3337706.
  135. Zehnaly A, Hosokawa R, Urata M, Chai Y. (2007) TGF-beta signaling and aplasia cutis congenita: proposed animal model. J Calif Dent Assoc. 2007 Dec;35(12):865-9. PMID: 18240750.
  136. Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. (2007) Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 2007 May 1;305(1):90-102. doi: 10.1016/j.ydbio.2007.01.038. Epub 2007 Feb 7. PMID: 17335794; PMCID: PMC1892170.
  137. Han J, Ishii M, Bringas P Jr, Maas RL, Maxson RE Jr, Chai Y. (2007) Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev. 2007 Sep-Oct;124(9-10):729-45. doi: 10.1016/j.mod.2007.06.006. Epub 2007 Jul 10. PMID: 17693062; PMCID: PMC2220014.
  138. Dudas M, Kim J, Li WY, Nagy A, Larsson J, Karlsson S, Chai Y, Kaartinen V. (2006) Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol. 2006 Aug 15;296(2):298-314. doi: 10.1016/j.ydbio.2006.05.030. Epub 2006 May 27. PMID: 16806156; PMCID: PMC1557652.
  139. Choudhary B, Ito Y, Makita T, Sasaki T, Chai Y, Sucov HM. (2006) Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol. 2006 Jan 15;289(2):420-9. doi: 10.1016/j.ydbio.2005.11.008. Epub 2005 Dec 5. PMID: 16332365.
  140. Chai Y, Maxson RE Jr. Recent advances in craniofacial morphogenesis. (2006) Dev Dyn. 2006 Sep;235(9):2353-75. doi: 10.1002/dvdy.20833. PMID: 16680722.
  141. Zhao H, Bringas P Jr, Chai Y. (2006) An in vitro model for characterizing the post-migratory cranial neural crest cells of the first branchial arch. Dev Dyn. 2006 May;235(5):1433-40. doi: 10.1002/dvdy.20588. PMID: 16245337; PMCID: PMC3337696.
  142. Xu X, Han J, Ito Y, Bringas P Jr, Urata MM, Chai Y. (2006) Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion. Dev Biol. 2006 Sep 1;297(1):238-48. doi: 10.1016/j.ydbio.2006.05.014. Epub 2006 May 19. PMID: 16780827.
  143. Sasaki T, Ito Y, Bringas P Jr, Chou S, Urata MM, Slavkin H, Chai Y. (2006) TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development. 2006 Jan;133(2):371-81. doi: 10.1242/dev.02200. PMID: 16368934.
  144. Sasaki T, Ito Y, Xu X, Han J, Bringas P Jr, Maeda T, Slavkin HC, Grosschedl R, Chai Y. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol. 2005 Feb 1;278(1):130-43. doi: 10.1016/j.ydbio.2004.10.021. PMID: 15649466.
  145. Xu X, Bringas P Jr, Soriano P, Chai Y. (2005) PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis. Dev Dyn. 2005 Jan;232(1):75-84. doi: 10.1002/dvdy.20197. PMID: 15543606.
  146. Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E. (2005) A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol. 2005 Jan;3(1):e11. doi: 10.1371/journal.pbio.0030011. Epub 2004 Dec 28. PMID: 15630473; PMCID: PMC539061.
  147. Plikus MV, Zeichner-David M, Mayer JA, Reyna J, Bringas P, Thewissen JG, Snead ML, Chai Y, Chuong CM. (2005) Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev. 2005 Sep-Oct;7(5):440-57. doi: 10.1111/j.1525-142X.2005.05048.x. PMID: 16174037; PMCID: PMC4386657.
  148. Cui XM, Shiomi N, Chen J, Saito T, Yamamoto T, Ito Y, Bringas P, Chai Y, Shuler CF. (2005) Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate. Dev Biol. 2005 Feb 1;278(1):193-202. doi: 10.1016/j.ydbio.2004.10.023. PMID: 15649471.
  149. Hosokawa R, Urata MM, Ito Y, Bringas P Jr, Chai Y. (2005) Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing. J Invest Dermatol. 2005 Dec;125(6):1302-9. doi: 10.1111/j.0022-202X.2005.23963.x. PMID: 16354202.
  150. Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE Jr. (2005) Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov;132(22):4937-50. doi: 10.1242/dev.02072. Epub 2005 Oct 12. PMID: 16221730.
  151. Ito Y, Yeo JY, Chytil A, Han J, Bringas P Jr, Nakajima A, Shuler CF, Moses HL, Chai Y. (2003) Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development. 2003 Nov;130(21):5269-80. doi: 10.1242/dev.00708. PMID: 12975342.
  152. Han J, Ito Y, Yeo JY, Sucov HM, Maas R, Chai Y. (2003) Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003 Sep 1;261(1):183-96. doi: 10.1016/s0012-1606(03)00300-2. PMID: 12941628.
  153. Cui XM, Chai Y, Chen J, Yamamoto T, Ito Y, Bringas P, Shuler CF. (2003) TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion. Dev Dyn. 2003 Jul;227(3):387-94. doi: 10.1002/dvdy.10326. PMID: 12815624.
  154. Chai Y, Slavkin HC. (2003) Prospects for tooth regeneration in the 21st century: a perspective. Microsc Res Tech. 2003 Apr 1;60(5):469-79. doi: 10.1002/jemt.10287. PMID: 12619122.
  155. Chai Y, Ito Y, Han J. (2003) TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells. Crit Rev Oral Biol Med. 2003;14(2):78-88. doi: 10.1177/154411130301400202. PMID: 12764071.
  156. Zhang Y, Wang S, Song Y, Han J, Chai Y, Chen Y. (2003) Timing of odontogenic neural crest cell migration and tooth-forming capability in mice. Dev Dyn. 2003 Apr;226(4):713-8. doi: 10.1002/dvdy.10274. PMID: 12666208.
  157. Xu X, Jeong L, Han J, Ito Y, Bringas P Jr, Chai Y. (2003) Developmental expression of Smad1-7 suggests critical function of TGF-beta/BMP signaling in regulating epithelial-mesenchymal interaction during tooth morphogenesis. Int J Dev Biol. 2003 Feb;47(1):31-9. PMID: 12653249.
  158. Jaskoll T, Zhou YM, Chai Y, Makarenkova HP, Collinson JM, West JD, Hajihosseini MK, Lee J, Melnick M. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002;170(2-3):83-98. doi: 10.1159/000046183. PMID: 11731698.
  159. Jitpukdeebodintra S, Chai Y, Snead ML. (2002) Developmental patterning of the circumvallate papilla. Int J Dev Biol. 2002 Aug;46(5):755-63. PMID: 12216988.
  160. Ito Y, Bringas P Jr, Mogharei A, Zhao J, Deng C, Chai Y. (2002) Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development. Dev Dyn. 2002 May;224(1):69-78. doi: 10.1002/dvdy.10088. PMID: 11984875.
  161. Acosta JM, Chai Y, Meara JG, Bringas P Jr, Anderson KD, Warburton D. (2001) Prenatal exposure to nitrofen induces Fryns phenotype in mice. Ann Plast Surg. 2001 Jun;46(6):635-40. doi: 10.1097/00000637-200106000-00012. PMID: 11405365.
  162. Ito Y, Zhao J, Mogharei A, Shuler CF, Weinstein M, Deng C, Chai Y. (2001) Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J Biol Chem. 2001 Nov 23;276(47):44163-72. doi: 10.1074/jbc.M011424200. Epub 2001 Sep 13. PMID: 11557747.
  163. Ito Y, Sarkar P, Mi Q, Wu N, Bringas P Jr, Liu Y, Reddy S, Maxson R, Deng C, Chai Y. (2001) Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis. Dev Biol. 2001 Aug 1;236(1):181-94. doi: 10.1006/dbio.2001.0332. PMID: 11456453.
  164. Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM. (2000) Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development. 2000 Apr;127(8):1671-9. doi: 10.1242/dev.127.8.1671. PMID: 10725243.
  165. Zhao J, Crowe DL, Castillo C, Wuenschell C, Chai Y, Warburton D. (2000) Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis. Mech Dev. 2000 May;93(1-2):71-81. doi: 10.1016/s0925-4773(00)00281-1. PMID: 10781941.
  166. Sarkar PS, Appukuttan B, Han J, Ito Y, Ai C, Tsai W, Chai Y, Stout JT, Reddy S. (2000) Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat Genet. 2000 May;25(1):110-4. doi: 10.1038/75500. PMID: 10802668.
  167. Amano O, Bringas P, Takahashi I, Takahashi K, Yamane A, Chai Y, Nuckolls GH, Shum L, Slavkin HC. (1999) Nerve growth factor (NGF) supports tooth morphogenesis in mouse first branchial arch explants. Dev Dyn. 1999 Nov;216(3):299-310. doi: 10.1002/(SICI)1097-0177(199911)216:3<299::AID-DVDY8>3.0.CO;2-B. PMID: 10590481.
  168. Chai Y, Zhao J, Mogharei A, Xu B, Bringas P Jr, Shuler C, Warburton D. (1999) Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants. Mech Dev. 1999 Aug;86(1-2):63-74. doi: 10.1016/s0925-4773(99)00112-4. PMID: 10446266.
  169. Chai Y, Bringas P Jr, Shuler C, Devaney E, Grosschedl R, Slavkin HC. (1998) A mouse mandibular culture model permits the study of neural crest cell migration and tooth development. Int J Dev Biol. 1998 Jan;42(1):87-94. PMID: 9496790.
  170. Chai Y, Bringas P Jr, Mogharei A, Shuler CF, Slavkin HC. (1998) PDGF-A and PDGFR-alpha regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro. Dev Dyn. 1998 Dec;213(4):500-11. doi: 10.1002/(SICI)1097-0177(199812)213:4<500::AID-AJA14>3.0.CO;2-A. PMID: 9853970.
  171. Chai Y, Sasano Y, Bringas P Jr, Mayo M, Kaartinen V, Heisterkamp N, Groffen J, Slavkin H, Shuler C. (1997) Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo. Dev Dyn. 1997 Apr;208(4):526-35. doi: 10.1002/(SICI)1097-0177(199704)208:4<526::AID-AJA8>3.0.CO;2-K. PMID: 9097024.
  172. Slavkin HC, Chai Y, Hu CC, Mayo M, Bringas P Jr, Santos V. (1995) The role of growth factors in early tooth morphogenesis. In Z. Davidovitch (Ed.), Biological Basis for Tooth Eruption. CRC Press.
  173. Slavkin HC, Chai Y, Hu CC, Millar-Groff S, Bringas P. (1994) Intrinsic molecular determinants of tooth development from specification to root fonnation: a review. In Z. Davidovitch (Ed.), Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants. Harvard Society for the Advancement of Orthodontics.
  174. Chai Y, Mah A, Crohin C, Groff S, Bringas P Jr, Le T, Santos V, Slavkin HC. (1994) Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development. Dev Biol. 1994 Mar;162(1):85-103. doi: 10.1006/dbio.1994.1069. PMID: 8125201.
  175. Chai Y, Klauser DK, Denny PA, Denny PC. (1993) Proliferative and structural differences between male and female mouse submandibular glands. Anat Rec. 1993 Feb;235(2):303-11. doi: 10.1002/ar.1092350214. PMID: 8420398.
  176. Denny PC, Chai Y, Klauser DK, Denny PA. (1993) Parenchymal cell proliferation and mechanisms for maintenance of granular duct and acinar cell populations in adult male mouse submandibular gland. Anat Rec. 1993 Mar;235(3):475-85. doi: 10.1002/ar.1092350316. PMID: 8430917.
  177. Chai Y, Crohin C, Groff S, Bringas P Jr, Santos V, Slavkin, HC. (1992) Suggested functions of endogenous TGFb isoforms in regulating mandibular morphogenesis and tooth formation. Selected Biomedical Research Summaries. Am. Society for Cell BioI. pp. 1-2.
  178. Slavkin HC, Hu CC, Sakakma Y, Diekwisch T, Chai Y, Mayo M, Bringas P Jr, Simmer J, Mak G, Sasano Y, David S. (1992) Gene Expression, Signal Transduction and Tissue-Specific Biominera1ization During Mammalian Tooth Development. In G.S. Stein, J.L. Stein, and J.B. Lian (Eds.), Critical Reviews in Eucaryotic Gene Expression. 2 (4): 315-330. Begell House.
  179. Slavkin HC, Shum L, Bringas P Jr, Sakakma Y, Chai Y, Mayo M, Santos V, Werb Z. (1992) EGF regulation of Meckel’s cartilage morphogenesis during mandibular morphogenesis in serumless, chemically-defined medium in vitro. In H.C. Slavkin and P. Price (Eds.) Chemistry and Biology of Mineralized Tissues. Pp.361-368. Elsevier Scientific Publications.
  180. Denny PC, Chai Y, Pimprapaiporn W, Denny PA. (1990) Three-dimensional reconstruction of adult female mouse submandibular gland secretory structures. Anat Rec. 1990 Apr;226(4):489-500. doi: 10.1002/ar.1092260411. PMID: 2331061.
  181. Denny PC, Chai Y, Klauser DK, Denny PA. (1990) Three-dimensional localization of DNA synthesis in secretory elements of adult female mouse submandibular gland. Adv Dent Res. 1990 Jun;4:34-44. doi: 10.1177/08959374900040010601. PMID: 2206211.
  182. Denny PA, Pimprapaiporn W, Bove BJ, Chai Y, Kim MS, Denny PC. (1989) Appearance of acinar-cell-specific mucin in prenatal mouse submandibular glands. Differentiation. 1989 May;40(2):93-8. doi: 10.1111/j.1432-0436.1989.tb00818.x. PMID: 2759365.
  183. Byrd KE, Chai Y. (1988) Three-dimensional movement analysis of lateral pterygoid electromyographic activity during mastication in the rat. Arch Oral Biol. 1988;33(9):635-40. doi: 10.1016/0003-9969(88)90116-1. PMID: 3245787.