Publications

Yu M, Ma, L, Yuan Y, Ye X, Montagne, A, He J, Ho T, Wu Y, Zhao Z, Maria NS, Jacobs R, Urata M, Wang H, Zlokovic BZ, Chen JF, Chai Y. (2021) Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis. Cell 184(1): P243-P256.

Zhao H, Feng J, Ho TV, Grimes WC, Urata MM, and Chai Y. 2015. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nature Cell Biology 17, 386-396.

Chai Y, Jiang X, Ito Y, Bringas, Jr. P, Han J, Rowitch D, Soriano P, McMahon A, and Sucov H. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127, 1671-1679.

Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, and Chai Y. 2014. Secretion of Shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 14, 160-173.

Xu X, Han J, Ito Y, Bringas P, Deng CX, and Chai Y. 2008. Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Developmental Cell 15, 322-329.

Iwata J, Suzuki A, Pelikan R, Ho TV, Sanchez-Lara PA, and Chai Y. 2014. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Human Molecular Genetics 23, 192-193.

Liu Y, Feng J, Li J, Zhao H, Ho TV, and Chai Y. 2015. An Nfic-Hedgehog signaling cascade regulates tooth root development. Development 142, 3374-3382.

Iwata J, Hacia J, Suzuki A, Sanchez-Lara PA, Urata MM, and Chai Y. 2012. Modulation of non-canonical TGF-beta signaling prevents cleft palate in Tgfbr2 mutant mice. Journal of Clinical Investigation 122, 873-885.

Parada C, Dong H, Grimaldi A, Sarrion P, Park SS, Pelikan R, Sanchez PA, and Chai Y. 2015. Disruption of ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development 142, 3734-3745.

Iwata J, Suzuki A, Yokota T, Ho TV, Urata MM, Sanchez PA, and Chai Y. 2014. TGF-beta-mediated WNT signaling regulates epithelial-mesenchymal interactions to control muscle development in the soft palate. Development 141, 909-917.

Han D, Zhao H, Parada C, Hacia J, Bringas P, and Chai Y. 2012. TGF-beta-Smad4-FGF6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development 139, 1640-1650.

Li J, Feng J, Liu Y, Ho TV, Grimes WC, Ho H, Park SS, Wang S, and Chai Y. 2015. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Developmental Cell 33, 125-135.

Ho TV, Iwata J, Ho HA, Grimes WC, Park SS, Sanchez-Lara PA, and Chai Y. 2015. Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Developmental Biology 400, 180-190.

Chen S, Jing J, Yuan Y, Feng J, Han X, Wen Q, Ho TV, Lee C, Chai Y.(2020) Runx2+ niche cells maintain mesenchymal tissue homeostasis through IGF signaling. Cell Reports 32(6): 108007. doi: 10.1016/j.celrep.2020.108007

Yuan Y, Loh YE, Han X, Feng J, Ho T, He J, Jing J, Groff K, Wu A, Chai Y. (2020) Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Science Advances 6(51): eabb0119.

Samuels BD ... Chai Y. (2020) FaceBase 3: Analytical Tools and FAIR Resources for Craniofacial and Dental Research. Development 147(18): dev191213.

 

  1. Pei F, Guo T, Zhang M, Ma L, Jing J, Feng J, Ho T-V, Wen Q, Chai Y. FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development. Bone Res 12, 37 (2024). https://doi.org/10.1038/s41413-024-00345-5.
  2. Zhang M, Guo T, Pei F, Feng J, Jing J, Xu J, Yamada T, Ho T-V, Du J, Sehgal P, Chai Y. ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling. Nat Commun 15, 4614 (2024). https://doi.org/10.1038/s41467-024-48285-2.
  3. Guo, T., Pei, F., Zhang, M., Yamada, T., Feng, J., Jing, J., Ho, T-V, and Chai, Y. Vascular architecture regulates mesenchymal stromal cell heterogeneity via p53-PDGF signaling in the mouse incisor. Cell Stem Cell. 2024 May 03. https://doi.org/10.1016/j.stem.2024.04.011.
  4. Pei F, Ma L, Guo T, Zhang M, Jing J, Wen Q, Feng J, Lei J, He J, Janeckova E, Ho TV, Chen JF, Chai Y. Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis. Development. 2024 Jan 15. https://doi.org/10.1242/dev.202043.
  5. Stanton E, Feng J, Kondra K, Sanchez J, Jimenez C, Brown KS, Skiles ML, Urata MM, Chai Y, Hammoudeh JA. A Calvarial Defect Model to Investigate the Osteogenic Potential of Umbilical Cord Stem Cells in Bone Regeneration. Plast Reconstr Surg. 2024 Mar 1;153(3):637-646. doi: 10.1097/PRS.0000000000010754. Epub 2023 May 24. PMID: 37224290.
  6. Zhang M, Feng J, Li Y, Qin PZ, Chai Y. Generation of tamoxifen-inducible Tfap2b-CreERT2 mice using CRISPR-Cas9. Genesis. 2023 Dec 8:e23582. doi: 10.1002/dvg.23582. Epub ahead of print. PMID: 38069547.
  7. Ma, L., Chang, Q., Pei, F., Liu, M., Zhang, W., Hong, Y-K., Chai, Y., Chen, JF. Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis. Cell Stem Cell (2023), https://doi.org/10.1016/j.stem.2023.09.012.
  8. Janečková E, Feng J, Guo T, Han X, Ghobadi A, Araujo-Villalba A, Rahman MS, Ziaei H, Ho TV, Pareek S, Alvarez J, Chai Y. Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis. Development. 2023 Mar 1;150(5):dev201189. doi: 10.1242/dev.201189. Epub 2023 Mar 9. PMID: 36825984; PMCID: PMC10108707.
  9. Black, N. and Chai, Y. Current understanding of the regulatory mechanism of tooth root development and future perspective. J Calif Dent. Assoc. 2023, Mar. PMCID: PMC10168653.
  10. Pei F, Ma L, Jing J, Feng J, Yuan Y, Guo T, Han X, Ho T-V, Lei J, He J, Zhang M, Chen J-F, Chai Y. (2023) Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. Nat Commun 14, 344. https://doi.org/10.1038/s41467-023-35977-4.
  11. Jing J, Zhang M, Guo T, Pei F, Yang Y, and Chai Y. (2022) Rodent incisor as a model to study mesenchymal stem cells in tissue homeostasis and repair. Front. Dent. Med, 30 November 2022, Volume 3 – 2022. https://doi.org/10.3389/fdmed.2022.1068494.
  12. Feng, J., Han X., Yuan Y., Cho, C.K., Janečková, E., Guo T., Pareek, S., Rahman, M.S., Zheng, B., Bi, J., Jing, J.J., Zhang, M., Xu, J., Ho, T.H., Chai, Y. (2022). TGF-B signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. eLife. https://doi.org/10.7554/eLife.80405.
  13. Stanton, E. Urata, M., Sheridan, S., and Chai, Y. (2022) From Bedside to Bench and Back: Advancing our Understanding of the Pathophysiology of Cleft Palate and Implications for the Future. The Cleft Palate-Craniofacial Journal, in press.
  14. Jing J, Feng J, Yuan Y, Guo T, Lei J, Pei F, Ho TV, Chai Y. (2022) Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 13,4803 (2022). https://doi.org/10.1038/s41467-022-32490-y.
  15. Gu, R., Zhang, S., Saha, S.K., Ji, Y., Reynolds, K., McMahon, M., Sun, B., Islam, M., Trainor, P., Chen, Y., Xu, Y., Chai, Y., Burkart-Waco, D., and Zhou, C. (2022) Single-cell transcriptomics and gene-regulatory networks modulated by Wntless in mammalian midline facial formation and clefts. Development. 15 July 2022; 149 (14): dev200533. doi:10.1242/dev.200533.
  16. Schuler, R. E., Bugacov, A., Hacia, J. G., Ho, T. V., Iwata, J., Pearlman, L., Samuels, B. D., Williams, C., Zhao, Z., Kesselman, C., & Chai, Y. (2022). FaceBase: A Community-Driven Hub for Data-Intensive Research. Journal of Dental Research. doi:10.1177/00220345221107905.
  17. Stanton E, Urata M, Chen JF, Chai Y.(2022) The clinical manifestations, molecular mechanisms, and treatment of craniosynostosis. Dis Model Mech. 2022 Apr 1;15(4):dmm049390. doi: 10.1242/dmm.049390. Epub 2022 Apr 22. PMID: 35451466; PMCID: PMC9044212.
  18. Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho T-V, Xu J, Chai Y. (2022) KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis. eLife. 2022 Feb 25;11:e74595. doi: 10.7554/eLife.74595. PMID: 35212626; PMCID: PMC9007587
  19. Ting MC, Farmer DT, Teng CS, He J, Chai Y, Crump JG, Maxson RE. Embryonic requirements for Tcf12 in the development of the mouse coronal suture. Development. 2022 Jan 1;149(1):dev199575. doi: 10.1242/dev.199575. Epub 2022 Jan 4. PMID: 34878091; PMCID: PMC8783042.
  20. Lei J, Chen S, Jing J, Guo T, Feng J, Ho TV, Chai Y. (2021) Inhibiting Hh signaling in Gli1+ osteogenic progenitors alleviates TMJOA. Journal of Dental Research. 2022.
  21. Ma L, Wang J, Ge JL, Wang Y, Zhang W, Du YN, Luo J, Li YP, Wang F, Fan GP, Chen R, Yao B, Zhao Z, Guo ML, Kim WK, Chai Y, Chen JF. (2021) Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus. EMBO Rep. 2021.
  22. Du J, Jing J, Chen S, Yuan Y, Feng J, Ho T-V, Sehgal P, Xu J, Jiang X, Chai Y.(2021) Arid1a regulates cell cycle exit of transit-amplifying cells through inhibiting the Aurka-Cdk1 axis in mouse incisor.  Development 2021: dev.198838 doi: 10.1242/dev.198838
  23. Du J, Jing J, Yuan Y, Feng J, Han X, Chen S, Li X, Peng W, Xu J, Ho T-V, Jiang X, Chai Y. 2021.
    Arid1a-Plagl1-Hh Signaling Is Indispensable for Differentiation-associated Cell Cycle Arrest of Tooth Root Progenitors. Cell Reports 35(1): 108007. doi: 10.1016/j.celrep.2021.108964.
  24. Johnson ZM, Yuan Y, Li X, Jashashvili T, Jamieson M, Urata M, Chen Y, Chai Y. 2021. Mesenchymal stem cells and 3D-osteoconductive scaffold regenerate calvarial bone in critical size defects in swine. Stem Cells Translational Medicine. 2021 April 1. doi: 10.1002/sctm.20-0534. PubMed PMID: 33794062. 
  25. Han X, Feng J, Guo T, Loh YE, Yuan Y, Ho TV, Cho C, Li J, Jing J, Janeckova E, He J, Pei F, Bi J, Song B, Chai Y (2021) Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. eLife. 2021 Jan 22; 10:e62387. doi: 10.7554/eLife.62387. PMID: 33482080.
  26. He J, Jing J, Feng J, Han X, Yuan Y, Guo T, Pei F, Ma Y, Cho C, Ho TV, Chai Y (2021) Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning. PLoS Genetics. 2021 Feb 17;17(2):31009320. doi: 10.1371/journal.pgen.1009320. PMID: 33596195
  27. Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. (2021) Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis. Cell. 2021 Jan 7; 184 (1) doi: 10.1016/j.cell/2020.11.037
  28. Jing J, Feng J, Li J, Zhao H, Ho T, He J, Yuan Y, Guo T, Du J, Urata M, Sharpe P, Chai Y. (2020) Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis. eLife 2021;10:e59459. doi: 10.7554/eLife.59459
  29. Ma Y, Jing J, Feng J, Yuan Y, Wen Q, Han X, He J, Chen S, Ho T, Chai Y. (2021) Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during root development. Development 2021 148: dev196360. doi: 10.1242/dev.196360
  30. Yuan Y, Loh YE, Han X, Feng J, Ho TV, He J, Jing J, Groff K, Wu A, and Chai Y. (2020) Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Science Advances. 2020 Dec 16; 6 (51): doi: DOI: 10.1126/sciadv.abb0119
  31. Men Y, Wang Y, Yi Y, Jing D, Luo W, Chai Y, Ge WP, Shen B, Stenberg W, Feng JQ, Zhao H. (2020) Gli1+ periodontium stem cells are regulated by osteocytes and occlusal force. Dev Cell. 2020 Sep 14;54(5):639-654.e6. doi:10.1016/j.devcel.2020.06.006. Epub 2020 Jul 10. PMID: 32652075.
  32.  Li X, Shan W, Yang Y, Joralmon D, Zhu Y, Chen Y, Yuan Y, Xu H, Rong J, Dai R, Nian Q, Chai Y, Chen Y. (2020) Limpet Tooth-Inspired Painless Microneedles Fabricated by Magnetic Field-Assisted 3D Printing. Adv. Funct. Mater. doi: 10.1002/adfm.202003725
  33. Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. (2020) FaceBase 3: Analytical Tools and FAIR Resources for Craniofacial and Dental Research. Development 147: dev191213. doi: 10.1242/dev.191213
  34. Chen S, Jing J, Yuan Y, Feng J, Han X, Wen Q, Ho TV, Lee C, Chai Y.(2020) Runx2+ niche cells maintain mesenchymal tissue homeostasis through IGF signaling. Cell Reports 32(6): 108007. doi: 10.1016/j.celrep.2020.108007
  35. Wen Q, Jing J, Han X, Feng J, Yuan Y, Ma Y, Chen S, Ho T-V, Chai Y.(2020) Runx2 regulates mouse tooth root development via activation of WNT inhibitor Notum. Journal of Bone and Mineral Research, 35(11):2252-2264. doi: 10.1002/jbmr.4120
  36. Jackson-Weaver O, Ungvijanpunya N, Yuan Y, Qian J, Gou Y, Wu J, Shen H, Chen Y, Li M, Richard S, Chai Y, Sucov HM, Xu J. (2020) PRMT1-p53 Pathway Controls Epicardial EMT and Invasion. Cell Rep. 2020 Jun 9;31(10):107739. doi: 10.1016/j.celrep.2020.107739. PMID: 32521264; PMCID: PMC7425665.
  37. Zhang W, Ma L, Yang M, Shao Q, Xu J, Lu Z, Zhao Z, Chen R, Chai Y, Chen JF. (2020) Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes Dev. 2020 Feb 27. doi: 10.1101/gad.332494.119. [Epub ahead of print] PubMed PMID: 32115408.
  38. Li X, Yuan Y, Liu L, Leung YS, Chen Y, Guo Y, Chai Y, Chen Y. (2019) 3d printing of hydroxyapatite/tricalcium phosphate scaffold with hierarchical porous structure for bone regeneration. Bio-Design & Manufacturing 3: 15-29. doi: 10.1007/s42242-019-00056-5
  39. Zhang C, Lin J, Nguyen NY, Guo Y, Xu C, Seo C, Villafana E, Jimenez H, Chai Y, Guan R, Liu H. (2019) Antimicrobial Bioresorbable Mg-Zn-Ca Alloy for Bone Repair in a Comparison Study with Mg-Zn-Sr Alloy and Pure Mg. ACS Biomaterials Science & Engineering 6(1): 517-538. doi: 10.1021/acsbiomaterials.9b00903. 
  40. Janečková E, Feng J, Li J, Rodriguez G, Chai Y. (2019) Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development. PLOS ONE 14(10):e0223879. doi: 10.1371/journal.pone.0223879. PMCID PMC6793855
  41. Jing J, Feng J, Li J, Han X, He J, Ho TV, Du J, Urata MM, Chai Y. (2019) Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars eLife 2019 Jul 1; 8. e46426. doi: 10.7554/eLife.46426. PMCID: PMC6602580.
  42. Shi C, Yuan Y, Guo Y, Jing J, Ho TV, Han X, Li J, Feng J, Chai Y. (2019) BMP signaling in regulating mesenchymal stem cells in incisor homeostasis. Journal of Dental Research 98(8) 904-911. doi: 10.1177/0022034519850812. PMCID PMC6616121
  43. Li J, Rodriguez G, Han X, Janečková E, Kahng S, Song B, Chai Y. (2019) Regulatory mechanisms of soft palate development and malformations. Journal of Dental Research 98(9): 959-967. doi: 10.1177/0022034519851786. PMCID: PMC6651766.
  44. Yuan Y & Chai Y. (2019) Regulatory mechanisms of jaw bone and tooth development. Curr Top Dev Biol 133:91-118. doi: 10.1016/bs.ctdb.2018.12.013
  45. Youssef A Kousa, Huiping Zhu, Walid D Fakhouri, Yunping Lei, Akira Kinoshita, Raeuf R Roushangar, Nicole K Patel, A J Agopian, Wei Yang, Elizabeth J Leslie, Tamara D Busch, Tamer A Mansour, Xiao Li, Arianna L Smith, Edward B Li, Dhruv B Sharma, Trevor J Williams, Yang Chai, Brad A Amendt, Eric C Liao, Laura E Mitchell, Alexander G Bassuk, Simon Gregory, Allison Ashley-Koch, Gary M Shaw, Richard H Finnell, Brian C Schutte (2019) The TFAP2A–IRF6–GRHL3 genetic pathway is conserved in neurulation. Human Molecular Genetics, ddz010, doi: 10.1093/hmg/ddz010
  46. Guo Y, Yuan Y, Wu L, Ho TV, Jing J, Sugii H, Li J, Han X, Feng J, Guo C, Chai Y. (2018) BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair. Bone Research, 6, 1-13. PMCID: PMC6193039.
  47. Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y. (2018) Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Developmental Biology, 441(1), 191-203. PMCID: PMC6152919.
  48. Bobarnac Dogaru, G., Juneja, S.C., Shokrani, A., Hui, R., Chai, Y., and Pepper, JP (2018) The role of Hedgehog-responsive fibroblasts in facial nerve regeneration. Experimental Neurology, 303, 72-79. PMID: 29337143.
  49. Zhang, T., Ungvilanpunya, N., Jackson-Weaver-O., Guo, Y., Feng, J., Ho, T, Shen, Y., Liu, J., Richard, S., Jin., J., Hajishengallis, G., Chai, Y., and Xu, J (2018) Smad6 methylation represses NFκB activation and periodontal inflammation. JDR, 97, 810-819. PMID: 29420098.
  50. Giannobile, W. V., Chai, Y., Chen, Y., Healy, Klein, O., Lane, N., Longaker, M., Lotz, J., Mooney, D.J., Sfeir, C., Urata, M., Wagner, W., Wu, B., and Kohn, D. (2018) Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care. JDR, 97, 361-363.PMCID: PMC5863875.
  51. Guo, Y., Li, J., Jackson-Weaver, O., Wu, J., Gupta, R., Ho, T., Chen, Y., Li, M., Richard, S., Wang, J., Chai, Y., and Xu, J (2018) Protein arginine methyltransferase PRMT1 is essential for palatogenesis. JDR, 97, 1510-1518. PMID: 29986157.
  52. An, Z., Akily, B., Sabalic, M., Zong, G., Chai, Y., and Sharpe, P. (2018) Regulation of mesenchymal stem to transit-amplifying cell transition in the continuously growing mouse incisor. Cell Report, 23, 3102-3111.
  53. Sugii H, Grimaldi A, Li J, Parada C, Ho T-V, Feng J, Jing J, Yuan Y, Guo Y, Maeda H, and Chai Y. (2017) Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development. Development 144: 4037-4045. doi: 10.1242/dev.155176
  54. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y. (2017) BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development 144: 2560-2569. doi: 10.1242/dev.150136
  55. Tian H, Feng J, Li J, Ho TV, Yuan Y, Liu Y, Brindopke F, Figueiredo JC, Magee W III, Sanchez-Lara PA, Chai Y. (2017) Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Human Molecular Genetics 26(5): 860-872.
  56. Li J, Parada C, Harunaga J, and Chai Y. (2017) Cellular and molecular mechanisms of tooth root development. Development 144: 374-384. doi: 10.1242/dev.137216
  57. Sun Z, Yu W, Navarro MS, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. (2016) Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development 143: 4115-4126. doi:10.1242/dev.138883
  58. Park S, Zhao H, Urata M, Chai Y. (2016) Sutures possess strong regenerative capacity for calvarial bone injury. Stem Cells and Development 25: 1801-1807. PubMed PMID: 27762665.
  59. Feng J, Jing J, Sanchez-Lara PA, Bootwalla MS, Buckley J, Wu N, Yan Y, Chai Y. (2016) Generation and characterization of tamoxifen-inducible Pax9-CreER Knock-In Mice using CrispR/Cas9. Genesis. 2016 Jul 6. doi: 10.1002/dvg.22956. [Epub ahead of print] PubMed PMID: 27381449.
  60. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J; FaceBase Consortium, Chai Y. (2016) The FaceBase Consortium: A Comprehensive Resource for Craniofacial Researchers. Development. 2016 Jun 10. pii: dev.135434. [Epub ahead of print] PubMed PMID: 27287806.
  61. Burg ML, Chai Y, Yao CA, Magee W 3rd, Figueiredo JC. (2016)Epidemiology, Etiology, and Treatment of Isolated Cleft Palate.Front Physiol. 2016 Mar 1;7:67. doi: 10.3389/fphys.2016.00067. eCollection 2016. Review. PubMed PMID: 26973535; PubMed Central PMCID: PMC4771933.
  62. Grimaldi A, Parada C, Chai Y. (2015) A Comprehensive Study of Soft Palate Development in Mice. PLoS One. 2015 Dec 15;10(12):e0145018. doi:10.1371/journal.pone.0145018. eCollection 2015. PubMed PMID: 26671681; PubMed Central PMCID: PMC4687642.
  63. Parada C, Chai Y. (2015) Mandible and Tongue Development.Curr Top Dev Biol.2015;115:31-58. doi: 10.1016/bs.ctdb.2015.07.023. Epub 2015 Oct 1. PubMed PMID:26589920; PubMed Central PMCID: PMC4869709.
  64. Parada C, Han D, Grimaldi A, Sarrión P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y. (2015) Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 1;142(21):3734-45. doi:10.1242/dev.125328. Epub 2015 Sep 22. PubMed PMID: 26395480; PubMed Central PMCID: PMC4647211.
  65. Zhao H, Chai Y. (2015) Stem Cells in Teeth and Craniofacial Bones. J Dent Res. 2015 Nov;94(11):1495-501. doi: 10.1177/0022034515603972. Epub 2015 Sep 8. Review. PubMed PMID: 26350960; PubMed Central PMCID: PMC4622324.
  66. Liu Y, Feng JF, Li JY, Zhao Hu, Ho TV, Chai Y. (2015) An Nfic-Hedgehog Signaling Cascade Regulates Tooth Root Development. Development. 2015 Oct 1;142(19):3374-82. doi:10.1242/dev.127068. Epub 2015 Aug 20. PubMed PMID: 26293299; PubMed Central PMCID: PMC4631759.
  67. Li J, Feng J, Liu Y, Ho TV, Grimes W, Ho HA, Park S, Wang SL, Chai Y. (2015) BMP-SHH Signaling Network Controls Epithelial Stem Cell Fate via Regulation of Its Niche in the Developing Tooth. Dev Cell. 2015 Apr 20;33(2):125-35. doi:10.1016/j.devcel.2015.02.021. Epub 2015 Apr 9. PubMed PMID: 25865348; PubMed Central PMCID: PMC4406846.
  68. Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. (2015) The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr;17(4):386-96. doi: 10.1038/ncb3139. Epub 2015 Mar 23. PubMed PMID: 25799059; PubMed Central PMCID: PMC4380556.
  69. Kim TH, Bae CH, Lee JY, Lee JC, Ko SO, Chai Y, Cho ES. (2015)Temporo-spatial requirement of Smad4 in dentin formation.Biochem Biophys Res Commun. 2015 Apr 17;459(4):706-12. doi: 10.1016/j.bbrc.2015.03.014. Epub 2015 Mar 11. PubMed PMID:25770424.
  70. Ho TV, Iwata J, Ho HA, Grimes WC, Park S, Sanchez-Lara PA, Chai Y. (2015) Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Dev Biol. 2015 Apr 15;400(2):180-90. doi: 10.1016/j.ydbio.2015.02.010. Epub 2015 Feb 23. PubMed PMID: 25722190; PubMed Central PMCID: PMC4385433.
  71. Zhong Z, Zhao H, Mayo J, Chai Y. (2015) Different Requirements for Wnt Signaling in Tongue Myogenic Subpopulations. J Dent Res. 2015 Mar;94(3):421-9. doi:10.1177/0022034514566030. Epub 2015 Jan 9. PubMed PMID: 25576472; PubMed Central PMCID: PMC4336158.
  72. Slavkin HC, Sanchez-Lara PA, Chai Y, Urata M. (2014) A model for interprofessional health care: lessons learned from craniofacial teams. J Calif Dent Assoc. 2014 Sep;42(9):637-44. PubMed PMID: 25265730.
  73. Han A, Zhao H, Li J, Pelikan R, Chai Y. (2014) ALK5-Mediated Transforming Growth Factor β Signaling in Neural Crest Cells Controls Craniofacial Muscle Development via Tissue-Tissue Interactions. Mol Cell Biol. 2014 Aug 15;34(16):3120-31. doi:10.1128/MCB.00623-14. Epub 2014 Jun 9. PubMed PMID: 24912677; PubMed Central PMCID: PMC4135603.
  74. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. (2014) Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 6;14(2):160-73. doi:10.1016/j.stem.2013.12.013. PubMed PMID: 24506883; PubMed Central PMCID:PMC3951379.
  75. Iwata J, Suzuki A, Yokota T, Ho TV, Pelikan R, Urata M, Sanchez-Lara PA, Chai Y. (2014) TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014 Feb;141(4):909-17. doi: 10.1242/dev.103093. PubMed PMID: 24496627; PubMed Central PMCID: PMC3912833.
  76. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Chai Y. (2014) Modulation of Lipid Metabolic Defects Rescues Cleft Palate in Tgfbr2 Mutant Mice. Hum Mol Genet. 2014 Jan 1;23(1):182-93. doi: 10.1093/hmg/ddt410. Epub 2013 Aug 23. PubMed PMID: 23975680; PubMed Central PMCID: PMC3857953.
  77. Iwata J, Suzuki A, Pelikan RC, Ho TV, Chai Y. (2013) Non-canonical transforming growth factor beta (TGFβ) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem. 2013 Oct 11;288(41):29760-70. doi:10.1074/jbc.M113.493551. Epub 2013 Aug 15. PubMed PMID: 23950180; PubMed Central PMCID: PMC3795273.
  78. Xu X, Chen C, Akiyama K, Chai Y, Le AD, Wang Z, Shi S. (2013)Gingivae Contain Neural-crest- and Mesoderm-derived Mesenchymal Stem Cells. J Dent Res. 2013 Sep;92(9):825-32. doi: 10.1177/0022034513497961. Epub 2013 Jul 18. PubMed PMID:23867762; PubMed Central PMCID: PMC3744273
  79. Parada C, Li J, Iwata J, Suzuki A, Chai Y. (2013) CTGF Mediates Smad-Dependent Transforming Growth Factor β Signaling To Regulate Mesenchymal Cell Proliferation during Palate Development. Mol Cell Biol. 2013 Sep;33(17):3482-93. doi:10.1128/MCB.00615-13. Epub 2013 Jul 1. PubMed PMID: 23816882; PubMed Central PMCID: PMC3753855.
  80. Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY. (2013) Smad2 and MRTFB Cooperatively Regulate Vascular Smooth Muscle Differentiation from Neural Crest Cells. Circ Res. 2013 Sep 27;113(8):e76-86. doi: 10.1161/CIRCRESAHA.113.301921.Epub 2013 Jul 1. PubMed PMID: 23817199; PubMed Central PMCID: PMC3837448.
  81. Mima J, Koshino A, Oka K, Uchida H, Hieda Y, Nohara K, Kogo M, Chai Y, Sakai T. (2013) Regulation of the Epithelial Adhesion Molecule CEACAM1 Is Important for Palate Formation. PLoS One. 2013 Apr 17;8(4):e61653. doi: 10.1371/journal.pone.0061653. Print 2013. PubMed PMID: 23613893; PubMed Central PMCID: PMC3629100.
  82. Song Z, Liu C, Iwata J*, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y. (2013) Mice with tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12;288(15):10440-50. doi: 10.1074/jbc.M112.432286. Epub 2013 Mar 4. PubMed PMID: 23460641; PubMed Central PMCID: PMC3624426.
  83. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG. (2013)Identification of candidate downstream targets of TGF-bate signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013 Apr;114(4):796-807. doi:10.1002/jcb.24417. PubMed PMID: 23060211; PubMed Central PMCID: PMC3777336.
  84. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Urata M, Dixon MJ, Chai Y. (2013) Smad4-Irf6 genetic interaction and TGF-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013 Mar;140(6):1220-30. doi: 10.1242/dev.089615. Epub 2013 Feb 13. PubMed PMID: 23406900; PubMed Central PMCID: PMC3585659.
  85. Huang XF, Chai Y. (2012) Molecular Regulatory Mechanism of Tooth Root Development. Int J Oral Sci. 2012 Dec;4(4):177-81. doi: 10.1038/ijos.2012.61. Epub 2012 Dec 7.PubMed PMID: 23222990; PubMed Central PMCID: PMC3633063.
  86. Parada C, Chai Y. (2012) Roles of BMP signaling pathway in lip and palate development. Front Oral Biol. 2012;16:60-70. doi: 10.1159/000337617. Epub 2012 Jun 25. Review. PubMed PMID: 22759670; PubMed Central PMCID: PMC3661199.
  87. Stephens H, Jensen B, Carpiaux W, Sedghizadeh P, Chai Y. (2012) A collaborative approach to advance student research at the University of Southern California. J Calif Dent Assoc. 2012 May;40(5):433-6, 438-9. PubMed PMID: 22685951.
  88. Han D, Zhao H, Parada C, Hacia JG, Bringas, Jr. P, Chai Y. (2012) A TGF-beta-Smad4-FGF6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development Development. 2012 May;139(9):1640-50. Epub 2012 Mar 21.PubMed PMID: 22438570; PubMed Central PMCID: PMC3317969.
  89. Iwata J, Hacia J, Suzuki A, Sanchez-Lara P, Urata M, Chai Y. (2012) Modulation of non-canonical TGF-beta signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar 1;122(3):873-85. doi: 10.1172/JCI61498. Epub 2012 Feb 13. PubMed PMID: 22326956; PubMed Central PMCID: PMC3287237.
  90. Parada C, Han D, Chai Y. (2012) Molecular and Cellular Regulatory Mechanisms of Tongue Myogenesis. J Dent Res. 2012 Jun;91(6):528-35. Epub 2012 Jan 4. Review.PubMed PMID: 22219210; PubMed Central PMCID: PMC3348065.
  91. Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y. (2012) Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor beta (TGFb) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20;287(4):2353-63. Epub 2011 Nov 28. PubMed PMID: 22123828;PubMed Central PMCID: PMC3268397.
  92. Huang XF, Yokota T, Iwata J, Chai Y. (2011) TGF-beta mediated FasL-Fas-Caspase pathway is crucial during palatogenesis. J Dent Res. 2011 Aug;90(8):981-7. Epub 2011 May 18. PubMed PMID: 21593251; PubMed Central PMCID: PMC3170164.
  93. Hung Y, Huang X, Chai Y. (2011) Molecular regulatory mechanism of root development. J Calif Dent Assoc. 2011 May;39(5):321-4. PubMed PMID: 21721476.
  94. Li J, Huang X, Xu X, Mayo J, Bringas P Jr, Jiang R, Wang S, Chai Y. (2011) SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis.Development. 2011 May;138(10):1977-89. Epub 2011 Apr 13. PubMed PMID: 21490069; PubMed Central PMCID: PMC3082303.
  95. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Iwata J, Marazita ML, Murray JC, Murray S, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. (2011) The FaceBase Consortium: A comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15;355(2):175-82. doi: 10.1016/j.ydbio.2011.02.033. Epub 2011 Mar 31. PubMed PMID: 21458441; PubMed Central PMCID: PMC3440302.
  96. Zhao H, Li S, Han D, Kaartinen V, Chai Y. (2011) Alk5-mediated TGF-beta signaling acts upstream of FGF10 to regulate the proliferation and maintenance of dental epithelial stem cells.Mol Cell Biol.2011 May;31(10):2079-89. Epub 2011 Mar 14. PubMed PMID: 21402782; PubMed Central PMCID: PMC3133354.
  97. Iwata J, Parada C, Chai Y. (2011) The mechanism of TGF-beta signaling during palatogenesis. Oral Dis. 2011 Nov;17(8):733-44. doi:10.1111/j.1601-0825.2011.01806.x. Epub 2011 Mar 13. Review. PubMed PMID:21395922; PubMed Central PMCID: PMC3329177.
  98. Chung IH, Han J, Iwata J, Chai Y. (2010) Msx1 and Dlx5 function synergistically to regulate frontal bone development.Genesis. 2010 Nov;48(11):645-55. doi:10.1002/dvg.20671. Epub 2010 Nov 2. PubMed PMID: 20824629; PubMed Central PMCID: PMC2995851.
  99. Jinno H, Morozova O, Jones KL, Biernaskie JA, Paris M, Hosokawa R, Rudnicki MA, Chai Y, Rossi F, Marra MA, Miller FD. (2010) Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Stem Cells. 2010 Nov;28(11):2027-40. doi: 10.1002/stem.525. PubMed PMID: 20848654; PubMed Central PMCID: PMC3087810.
  100. He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y. (2010) Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 1;347(1):109-21. Epub 2010 Aug 19. PubMed PMID: 20727875; PubMed Central PMCID: PMC3010875.
  101. Lu L, Wang J, Zhang F, Chai Y, Brand D, Wang X, Horwitz DA, Shi W, Zheng SG. (2010) Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol. 2010 Apr 15;184(8):4295-306. Epub 2010 Mar 19. PubMed PMID: 20304828; PubMed Central PMCID: PMC3087811.
  102. Hosokawa R, Oka K, Yamaza T, Iwata J, Urata M, Xu X, Bringas P Jr, Nonaka K, Chai Y. (2010) TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol. 2010 May 1;341(1):186-95. Epub 2010 Feb 26. PubMed PMID: 20193675; PubMed Central PMCID: PMC3336866.
  103. Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y. (2010) Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J Biol Chem. 2010 Feb 12;285(7):4975-82. PubMed PMID: 19959467; PubMed Central PMCID: PMC2836101.
  104. Chai Y. (2010) Towards a molecular understanding of cleft palate. Beijing Da Xue Xue Bao. 42(1):9-13. PubMed PMID: 20429146.
  105. Huang XF, Xu X, Bringas P Jr, Hung YP, Chai Y. (2010) Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development. J Bone Miner Res. 2010 May;25(5):1167-78. PubMed PMID:19888897; PubMed Central PMCID: PMC3153373.
  106. Han J, Mayo J, Xu X, Li JY, Bringas P Jr, Mass RL, Rubenstein JLR, Chai Y. (2009) Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec;136(24):4225-33. PubMed PMID: 19934017; PubMed Central PMCID: PMC2781056.
  107. Huang XF, Bringas P, Slavkin HC, Chai Y. (2009) Fate of HERS during Tooth Root Development. Dev. Biol. 334(1):22-30. PubMed PMID: 19576204; PubMed Central PMCID: PMC2744848.
  108. Oka K, Oka S, Chai Y. (2009) The Role of TGF-β Signaling in Cranial Neural Crest Cells during Mandibular and Tooth Development J. Oral Biosci. 51(3), 143-150
  109. Hosokawa R, Deng X, Takamori K, Xu X, Urata M, Bringas Jr. P, Chai Y. (2009) Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. J. Exp. Zoology 312B(4):343-350. PubMed PMID: 19235875; PubMed Central PMCID: PMC2896559.
  110. Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixson A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Muller R, Chai Y, Smith E, Bab I, Frenkel B. (2009)Lef1 haploinsufficiency mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner.PLoS ONE 4(5):e5438. PubMed PMID: 19412553; PubMed Central PMCID: PMC2673053.
  111. Chung I, Yamaza T, Zhao H. Choung P, Shi S, Chai Y. (2009)Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. Stem Cells 27(4):866-77. PubMed PMID: 19350689; PubMed Central PMCID: PMC2896558.
  112. Shi S, Chai Y, Slavkin H. (2009) Emerging opportunities for the next generation of dental implants? Dent Today 28(3):98-9. PubMed PMID: 19323323.
  113. Zhang Z, Lan Y, Chai Y, Jiang, R. (2009) Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into single row.Science 323(5918):1232-4. PubMed PMID: 19251632; PubMed Central PMCID: PMC2650836.
  114. Anthwal N, Chai Y, Tucker AS. (2008) The Role of Transforming Growth Factor-beta Signalling in the Patterning of the Proximal Processes of the Murine Dentary. Dev. Dyn. 237(6):1604-13. PubMed PMID: 18498113.
  115. Chen H, Zhuang F, Liu YH, Xu B, Del Moral P, Deng W, Chai Y, Kolb M, Gauldie J, Warburton D, Moses HL, Shi W. (2008)TGF-beta receptor II in Epithelia Versus Mesenchyme Plays Distinct Role in Developing Lung. Eur Respir J. 32(2):285-95. PubMed PMID: 18321928; PubMed Central PMCID: PMC2865234.
  116. De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S. (2008)Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS One. 2008 Jan 30;3(1):e1516. PubMed PMID: 18231602; PubMed Central PMCID: PMC2211394.
  117. Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S. (2008) PDGF regulates salivary gland morphogenesis via FGF expression. J Biol Chem. 283(34):23139-23149. PubMed PMID: 18559345.
  118. Zhao H, Oka K, Bringas P, Kaartinen V, Chai Y (2008) TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008 Aug 1;320(1):19-29. doi: 10.1016/j.ydbio.2008.03.045. Epub 2008 Apr 15. PubMed PMID: 18572160; PubMed Central PMCID: PMC3629921.
  119. Oka K, Oka S, Hosokawa R, Bringas Jr. P, Brockhoff II HC, Nonaka K, Chai Y (2008) TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol. 2008 Sep 15;321(2):303-9. doi: 10.1016/j.ydbio.2008.03.046. Epub 2008 Apr 15. PubMed PMID:18684439; PubMed Central PMCID: PMC3378386.
  120. Takamori K, Hosokawa R, Xu X, Deng X, Bringas P Jr, Chai Y. (2008) Epithelial fibroblast growth factor receptor 1 regulates enamel formation. J Dent Res. 87(3):238-43. PubMed PMID: 18296607.
  121. Xing Y, Li C, Hu L, Tiozzo C, Li M, Chai Y, Bellusci S, Anderson S, Minoo P. (2008) Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: The role of TbetaRII, Smads, Nkx2.1 and Pten. Dev Biol. 320(2):340-50. PubMed PMID: 18602626; PubMed Central PMCID: PMC2597224.
  122. Xu X, Han J, Ito Y, Bringas Jr. P, Deng C, Chai, Y. (2008)Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Dev. Cell. 15(2):322-9. PubMed PMID: 18694570; PubMed Central PMCID: PMC2610417.
  123. Oka K, Oka S, Sasaki T, Ito Y, Bringas P Jr., Nonaka K, and Chai Y. (2007) The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev. Biol. 303(1):391-404. PubMed PMID: 17204263; PubMed Central PMCID: PMC2074881.
  124. Oka S, Oka K, Xu X, Sasaki T, Bringas P Jr, and Chai Y. (2007)Cell autonomous requirement for TGF-beta signaling during odontoblast differentiation and dentin matrix formation.Mechanism of Development 124(6):409-15. PubMed PMID: 17449229; PubMed Central PMCID: PMC2704601.
  125. Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng CX, Chai Y. (2007) Smad4 is required to regulate the fate of cranial neural crest cells. Dev. Biol. 312(1):435-47. PubMed PMID: 17964566; PubMed Central PMCID: PMC2704603.
  126. Pemberton TJ, Li FY, Oka S, Mendoza-Fandino GA, Hsu YH, Bringas P Jr, Chai Y, Snead ML, Mehrian-Shai R, Patel PI. (2007) Identification of novel genes expressed during mouse tooth development by microarray gene expression analysis. Dev Dyn. 2007 Aug;236(8):2245-57. PubMed PMID: 17626284; PubMed Central PMCID: PMC4457363.
  127. Hosokawa R, Urata M, Han J, Zehnaly A., Bringas Jr P, Nonaka K, Chai Y. (2007) TGF-beta mediated Msx2 expression controls occipital somites-derived caudal region of skull development.Dev Biol. 2007 Oct 1;310(1):140-53. Epub 2007 Aug 6. PubMed PMID: 17727833; PubMed Central PMCID: PMC3337706.
  128. Zehnaly A, Hosokawa R, Urata M, Chai Y. (2007) TGF-beta signaling and aplasia cutis congenita: proposed animal model. J Calif Dent Assoc. 35(12):865-9. PubMed PMID: 18240750.
  129. Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. (2007)Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 305(1):90-102. PubMed PMID: 17335794; PubMed Central PMCID: PMC1892170.
  130. Han J, Ishii M, Bringas P Jr, Maas RL, Maxson RE Jr, Chai Y. (2007) Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mechanisms of Development 124(9-10):729-45. PubMed PMID: 17693062; PubMed Central PMCID: PMC2220014.
  131. Dudas M, Kim J, Li WY, Nagy A, Larsson J, Karlsson S, Chai Y, Kaartinen V. (2006) Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol. 2006 Aug 15;296(2):298-314. Epub 2006 May 27. PubMed PMID: 16806156; PubMed Central PMCID: PMC1557652.
  132. Choudhary B, Ito Y, Makita T, Sasaki T, Chai Y, Sucov HM. (2006) Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol. 289(2):420-9. PubMed PMID: 16332365.
  133. Chai Y, Maxson RE. (2006) Recent Advances in Craniofacial Morphogenesis. Dev Dyn. 2006 Sep;235(9):2353-75. Review. PubMed PMID: 16680722.
  134. Zhao H, Bringas P Jr, Chai Y. (2006) An in vitro model for characterizing the post-migratory cranial neural crest cells of the first branchial arch. Dev Dyn. 235(5):1433-40. PubMed PMID: 16245337.
  135. Xu X, Han J, Ito Y, Bringas P Jr., Urata MM, Chai Y. (2006) Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion. Dev. Biol. 297(1):238-48. PubMed PMID: 16780827.
  136. Sasaki T, Ito Y, Bringas Jr. P, Chou S, Urata M, Slavkin HC, Chai Y. (2006) TGF-beta-mediated FGF signaling is critical for regulating cranial neural crest cell proliferation during frontal bone development. Development 133, 371-381
  137. Sasaki T, Ito Y, Xu X, Han J, Bringas Jr P, Maeda T, Slavkin HC, Grosschedl R, Chai Y. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev. Biol. 278,130-143.
  138. Xu X, Bringas P Jr, Soriano P, Chai Y. (2005) PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis.Dev. Dyn. 232(1):75-84
  139. Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E. (2005) A Signaling Pathway Involving TGF-beta2 and Snail in Hair Follicle Morphogenesis. PLoS Biol. 3(1):e11
  140. Plikus MV, Zeichner-David M, Mayer JA, Reyna J, Bringas P, Thewissen JGM, Snead ML, Chai Y, Chuong CM. (2005)Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evolution & Development 7:5, 440 -457
  141. Cui XM, Shiomi N, Chen J, Saito T, Yamamoto T, Ito Y, Bringas Jr. P, Chai Y, Shuler CF. (2005) Overexpression of Smad2 in TGF-beta3-null mutant mice rescues cleft palate. Dev. Biol. 278, 193-202.
  142. Hosokawa R, Urata MM, Ito Y, Bringas P Jr., Chai Y. (2005)Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing. J Inves Dermatol. 125: 1302-1309
  143. Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE Jr. (2005) Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 132(22):4937-50.
  144. Ito Y, Yeo JY, Chytil A, Han J, Bringas P Jr, Nakajima A, Shuler CF, Moses HL, Chai Y. (2003) Conditional inactivation of TGF-beta IIR in cranial neural crest causes cleft palate and calvaria defects. Development 130, 5269-5280.
  145. Han J., Ito Y., Yeo J., Sucov H.M., Maas R., and Chai Y. (2003)Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19INK4d expression during odontogenesis. Dev. Biol. 261, 183-196.
  146. Cui XM, Chai Y, Chen J, Yamamoto T, Ito Y, Bringas P, Shuler CF. (2003) TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion. Dev Dyn. 227:387-94.
  147. Chai Y. and Slavkin H.C. (2003) Prospects of tooth regeneration in the 21st century: a perspective. Micros. Res. Tech. 60(5):469-79
  148. Chai Y., Ito Y., and Han J. (2003) TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells. Crit. Rev. Oral Biol. Med. 14, 78-88.
  149. Zhang Y, Wang S, Song Y, Han J, Chai Y, Chen Y. (2003) Timing of odontogenic neural crest cell migration and tooth-forming capability in mice. Dev. Dyn. 226, 713-718
  150. Xu X, Jeong L, Han J, Ito Y, Bringas P Jr, Chai Y. (2003)Developmental expression of Smad1-7 suggests critical function of TGF-beta/BMP signaling in regulating epithelial-mesenchymal interaction during tooth morphogenesis. Int J Dev Biol 47(1):31-9
  151. Jaskoll T, Zhou Y, Chai Y, Makarenkova H, Collinson J, West J, Hajihosseini M, Lee J, Melnick M (2002) Embryonic Submandibular Gland Morphogenesis: Stage-Specific Protein Localization of FGFs, BMPs, Pax6 and Pax9 in Normal Mice and Abnormal SMG Phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) Mice. Cells Tissues Organs 170(2-3):83-98
  152. Jitpukdeebodintra S., Chai Y., and Snead ML. (2002)Developmental patterning of the circumvallate papilla. Int. J. Dev. Biol. 46, 755-763.
  153. Ito Y, Bringas P Jr, Mogharei A, Zhao J, Deng C, Chai Y. (2002)Receptor-regulated and inhibitory Smads in regulating TGF-beta-mediated Meckel s cartilage development. Dev.Dyn 224(1):69-78.
  154. Acosta JM, Chai Y, Meara JG, Bringas P Jr, Anderson KD, Warburton D (2001) Prenatal exposure to nitrofen indces Fryns phenotype in mice. Ann. Plast. Surg. 46, 635-640
  155. Ito Y, Zhao J, Mogharei A, Shuler CF, Weinstein M, Deng C, Chai Y (2001) Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J Biol Chem 276(47):44163-44172
  156. Ito Y, Sarkar P, Mi Q, Wu N, Bringas P Jr, Liu Y, Reddy S, Maxson R, Deng C, Chai Y (2001) Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis. Dev. Biol. 236, 181-194
  157. Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM (2000) Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development, 127,1671-1679.
  158. Zhao J, Crowe DL, Castillo C, Wuenschell C, Chai Y, Warburton D (2000) Smad7 is a TGF-beta- inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis. Mech. Dev. 93, 71-81.
  159. Sarkar PS, Appukuttan B, Han J, Ito Y, Ai C, Tsai W, Chai Y, Stout JT, Reddy S (2000) Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nature Genetics. 25, 110-114.
  160. Amano O, Bringas P, Takahashi I, Takahashi K, Yamane A, Chai Y, Nuckolls GH, Shum L, Slavkin HC (1999) Nerve Growth Factor (NGF) Induces Tooth Morphogenesis in Mouse First Branchial Arch Explants. Dev. Dyn. 216, 299-310.
  161. Chai Y, Zhao J, Mogharei A, Xu B, Bringas P Jr, Shuler C, Warburton D (1999) Inhibition of Transfom1ing Growth Factor p Type II Receptor Signaling Accelerates Tooth Formation in Mouse First Branchial Arch Explants. Mech. Dev. 86, 63-74.
  162. Chai Y, Bringas P Jr, Shuler C, Devaney E, Grosschedl R, Slavkin HC (1998) An early mandibular organ culture model developed to study cranial neural crest cell migration and molecular regulation of first branchial arch morphogenesis. Int. J Dev. Biol 42, 87-94.
  163. Chai Y, Bringas P Jr, Slavkin HC (1998) PDGF-A and PDGFR-alpha Regulate Tooth Fonnation During Mandibular Morphogenesis In Vitro. Dev. Dyn. 213, 500-511.
  164. Chai Y, Sasano Y, Bringas P, Mayo M, Slavkin HC, Shuler CF (1997) The characterization of the fate of midline epithelial cells during fusion of mandibular prominences in vivo. Dev. Dyn. 208. 526-535.
  165. Slavkin HC, Chai Y, Hu CC, Mayo M, Bringas P Jr, Santos V (1995) The role of growth factors in early tooth morphogenesis, In: Biological Basis for Tooth Eruption, ed. Z. Davidovitch CRC Press, Boca Ratan, Florida.
  166. Slavkin HC, Chai Y, Hu CC, Millar-Groff S, Bringas P (1994)Intrinsic molecular deteminants of tooth development from specification to root fonnation: a review. In: Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants.
  167. Chai Y, Mah A, Crohin C, Groff S, Bringas P, Le T, Santos V, Slavkin, H.C. (1994) Specific transfom1ing growth factor-beta subtypes regulate embryonic mouse Meckel’s cartilage and tooth development. Dev. Biol. 162. 85-103.
  168. Chai Y, Klauser DK, Denny PA, Denny PC (1993) Proliferative and structural differences. between male and female mouse submandibular glands. Anat. Rec. 235, 303-311.
  169. Denny PC, Chai Y, Klauser DK, Denny PA (1993) Parenchymal cell proliferation and mechanisms for maintenance of granular duct and acinar cell populations in adult male mouse submandibular gland. Anat. Rec. 235, 475-485.
  170. Chai Y, Crohin C, Groff S, Bringas P Jr, Santos V, Slavkin, HC (1992) Suggested functions of endogenous TGFb isoforms in regulating mandibular morphogenesis and tooth formation. Selected Biomedical Research Summaries Am. Society for Cell BioI. pp. 1-2.
  171. Slavkin HC, Hu CC, Sakakma Y, Diekwisch T, Chai Y, Mayo M, Bringas P Jr, Simmer J, Mak G, Sasano Y, David S (1992) Gene Expression, Signal Transduction and Tissue-Specific Biominera1ization During Mammalian Tooth Development, Critical Reviews in Eucaryotic Gene Expression, Stein, G. S., Stein, J. L., & Lian, J. B., editors, CRC Press. 2 (4): 315-330.
  172. Slavkin HC, Shum L, Bringas P Jr, Sakakma Y, Chai Y, Mayo M, Santos V, Werb Z (1992) EGF regulation of Meckel’s cartilage morphogenesis during mandibular morphogenesis in serumless, chemically-defined medium in vitro. ln: Chemistry and Biology of Mineralized Tissues (eds. Slavkin HC and Price P) Elsevier Scientific Publications, Amsterdam, pp.361-368.
  173. Denny PC, Chai Y, Pimprapaiporn W, Denny PA (1990) Three-dimensional reconstruction of adult female mouse sumandibular gland secretory structures Anat. Rec. 226, 489-500.
  174. Denny PC, Chai Y, Klauser DK, Denny PA (1990) Three-dimensional localization of DNA synthesis in secretory elements of adult female mouse submandibular gland. Advances in Dent. Res. 4, 34-44.
  175. Denny PA, Pimprapaiporn W, Bove BJ, Chai Y, Kim MS, Denny PC (1989) Appearance of acinar-cell-specific mucin in prenatal mouse submandloular gland Differentiation 40, 93-98.
  176. Byrd KE, Chai Y (1988) Three-dimensional movement analysis of lateral pterygoid eletromyographic activity during mastication in the rat. Arch. Oral Biol. 33,635-640.