Publications

Yu M, Ma, L, Yuan Y, Ye X, Montagne, A, He J, Ho T, Wu Y, Zhao Z, Maria NS, Jacobs R, Urata M, Wang H, Zlokovic BZ, Chen JF, Chai Y. (2021) Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis. Cell 184(1): P243-P256.

Zhao H, Feng J, Ho TV, Grimes WC, Urata MM, and Chai Y. 2015. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nature Cell Biology 17, 386-396.

Chai Y, Jiang X, Ito Y, Bringas, Jr. P, Han J, Rowitch D, Soriano P, McMahon A, and Sucov H. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127, 1671-1679.

Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, and Chai Y. 2014. Secretion of Shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell 14, 160-173.

Xu X, Han J, Ito Y, Bringas P, Deng CX, and Chai Y. 2008. Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Developmental Cell 15, 322-329.

Iwata J, Suzuki A, Pelikan R, Ho TV, Sanchez-Lara PA, and Chai Y. 2014. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Human Molecular Genetics 23, 192-193.

Liu Y, Feng J, Li J, Zhao H, Ho TV, and Chai Y. 2015. An Nfic-Hedgehog signaling cascade regulates tooth root development. Development 142, 3374-3382.

Iwata J, Hacia J, Suzuki A, Sanchez-Lara PA, Urata MM, and Chai Y. 2012. Modulation of non-canonical TGF-beta signaling prevents cleft palate in Tgfbr2 mutant mice. Journal of Clinical Investigation 122, 873-885.

Parada C, Dong H, Grimaldi A, Sarrion P, Park SS, Pelikan R, Sanchez PA, and Chai Y. 2015. Disruption of ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development 142, 3734-3745.

Iwata J, Suzuki A, Yokota T, Ho TV, Urata MM, Sanchez PA, and Chai Y. 2014. TGF-beta-mediated WNT signaling regulates epithelial-mesenchymal interactions to control muscle development in the soft palate. Development 141, 909-917.

Han D, Zhao H, Parada C, Hacia J, Bringas P, and Chai Y. 2012. TGF-beta-Smad4-FGF6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development 139, 1640-1650.

Li J, Feng J, Liu Y, Ho TV, Grimes WC, Ho H, Park SS, Wang S, and Chai Y. 2015. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Developmental Cell 33, 125-135.

Ho TV, Iwata J, Ho HA, Grimes WC, Park SS, Sanchez-Lara PA, and Chai Y. 2015. Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Developmental Biology 400, 180-190.

Chen S, Jing J, Yuan Y, Feng J, Han X, Wen Q, Ho TV, Lee C, Chai Y.(2020) Runx2+ niche cells maintain mesenchymal tissue homeostasis through IGF signaling. Cell Reports 32(6): 108007. doi: 10.1016/j.celrep.2020.108007

Yuan Y, Loh YE, Han X, Feng J, Ho T, He J, Jing J, Groff K, Wu A, Chai Y. (2020) Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Science Advances 6(51): eabb0119.

Samuels BD ... Chai Y. (2020) FaceBase 3: Analytical Tools and FAIR Resources for Craniofacial and Dental Research. Development 147(18): dev191213.

 

  1. Buchanan C, Chen S, Yuan Y, Guo T, Feng J, Zhang M, Carey G, Howard I, Sanchez J, Ho TV, Chai Y. Loss of Runx2 in Gli1+ osteogenic progenitors prevents bone loss following ovariectomy. JBMR Plus, Volume 9, Issue 1, January 2025, ziae141, https://doi.org/10.1093/jbmrpl/ziae141.
  2. Pei F, Guo T, Zhang M, Ma L, Jing J, Feng J, Ho T-V, Wen Q, Chai Y. FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development. Bone Res 12, 37 (2024). https://doi.org/10.1038/s41413-024-00345-5.
  3. Zhang M, Guo T, Pei F, Feng J, Jing J, Xu J, Yamada T, Ho T-V, Du J, Sehgal P, Chai Y. ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling. Nat Commun 15, 4614 (2024). https://doi.org/10.1038/s41467-024-48285-2.
  4. Guo, T., Pei, F., Zhang, M., Yamada, T., Feng, J., Jing, J., Ho, T-V, and Chai, Y. Vascular architecture regulates mesenchymal stromal cell heterogeneity via p53-PDGF signaling in the mouse incisor. Cell Stem Cell. 2024 May 03. https://doi.org/10.1016/j.stem.2024.04.011.
  5. Pei F, Ma L, Guo T, Zhang M, Jing J, Wen Q, Feng J, Lei J, He J, Janeckova E, Ho TV, Chen JF, Chai Y. Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis. Development. 2024 Jan 15. https://doi.org/10.1242/dev.202043.
  6. Stanton E, Feng J, Kondra K, Sanchez J, Jimenez C, Brown KS, Skiles ML, Urata MM, Chai Y, Hammoudeh JA. (2023) A Calvarial Defect Model to Investigate the Osteogenic Potential of Umbilical Cord Stem Cells in Bone Regeneration. (2023) Plast Reconstr Surg. 2024 Mar 1;153(3):637-646. doi: 10.1097/PRS.0000000000010754. Epub 2023 May 24. PMID: 37224290.
  7. Zhang M, Feng J, Li Y, Qin PZ, Chai Y. (2023) Generation of tamoxifen-inducible Tfap2b-CreERT2 mice using CRISPR-Cas9. Genesis. 2024 Feb;62(1):e23582. doi: 10.1002/dvg.23582. Epub 2023 Dec 8. PMID: 38069547; PMCID: PMC11021159.
  8. Ma, L., Chang, Q., Pei, F., Liu, M., Zhang, W., Hong, Y-K., Chai, Y., Chen, JF. (2023) Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis. Cell Stem Cell (2023), https://doi.org/10.1016/j.stem.2023.09.012.
  9. Janečková E, Feng J, Guo T, Han X, Ghobadi A, Araujo-Villalba A, Rahman MS, Ziaei H, Ho TV, Pareek S, Alvarez J, Chai Y. (2023) Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis. Development. 2023 Mar 1;150(5):dev201189. doi: 10.1242/dev.201189. Epub 2023 Mar 9. PMID: 36825984; PMCID: PMC10108707.
  10. Black, N. and Chai, Y. (2023) Current understanding of the regulatory mechanism of tooth root development and future perspective. J Calif Dent. Assoc. 2023, Mar. PMCID: PMC10168653.
  11. Pei F, Ma L, Jing J, Feng J, Yuan Y, Guo T, Han X, Ho T-V, Lei J, He J, Zhang M, Chen J-F, Chai Y. (2023) Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis. Nat Commun 14, 344. https://doi.org/10.1038/s41467-023-35977-4.
  12. Jing J, Zhang M, Guo T, Pei F, Yang Y, and Chai Y. (2022) Rodent incisor as a model to study mesenchymal stem cells in tissue homeostasis and repair. Front. Dent. Med, 30 November 2022, Volume 3 – 2022. https://doi.org/10.3389/fdmed.2022.1068494.
  13. Feng, J., Han X., Yuan Y., Cho, C.K., Janečková, E., Guo T., Pareek, S., Rahman, M.S., Zheng, B., Bi, J., Jing, J.J., Zhang, M., Xu, J., Ho, T.H., Chai, Y. (2022). TGF-B signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development. eLife. https://doi.org/10.7554/eLife.80405.
  14. Stanton, E. Urata, M., Sheridan, S., and Chai, Y. (2022) From Bedside to Bench and Back: Advancing our Understanding of the Pathophysiology of Cleft Palate and Implications for the Future. The Cleft Palate-Craniofacial Journal, in press.
  15. Jing J, Feng J, Yuan Y, Guo T, Lei J, Pei F, Ho TV, Chai Y. (2022) Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 13,4803 (2022). https://doi.org/10.1038/s41467-022-32490-y.
  16. Gu, R., Zhang, S., Saha, S.K., Ji, Y., Reynolds, K., McMahon, M., Sun, B., Islam, M., Trainor, P., Chen, Y., Xu, Y., Chai, Y., Burkart-Waco, D., and Zhou, C. (2022) Single-cell transcriptomics and gene-regulatory networks modulated by Wntless in mammalian midline facial formation and clefts. Development. 15 July 2022; 149 (14): dev200533. doi:10.1242/dev.200533.
  17. Schuler, R. E., Bugacov, A., Hacia, J. G., Ho, T. V., Iwata, J., Pearlman, L., Samuels, B. D., Williams, C., Zhao, Z., Kesselman, C., & Chai, Y. (2022). FaceBase: A Community-Driven Hub for Data-Intensive Research. Journal of Dental Research. doi:10.1177/00220345221107905.
  18. Stanton E, Urata M, Chen JF, Chai Y.(2022) The clinical manifestations, molecular mechanisms, and treatment of craniosynostosis. Dis Model Mech. 2022 Apr 1;15(4):dmm049390. doi: 10.1242/dmm.049390. Epub 2022 Apr 22. PMID: 35451466; PMCID: PMC9044212.
  19. Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho T-V, Xu J, Chai Y. (2022) KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis. eLife. 2022 Feb 25;11:e74595. doi: 10.7554/eLife.74595. PMID: 35212626; PMCID: PMC9007587
  20. Ting MC, Farmer DT, Teng CS, He J, Chai Y, Crump JG, Maxson RE. Embryonic requirements for Tcf12 in the development of the mouse coronal suture. Development. 2022 Jan 1;149(1):dev199575. doi: 10.1242/dev.199575. Epub 2022 Jan 4. PMID: 34878091; PMCID: PMC8783042.
  21. Lei J, Chen S, Jing J, Guo T, Feng J, Ho TV, Chai Y. (2021) Inhibiting Hh signaling in Gli1+ osteogenic progenitors alleviates TMJOA. Journal of Dental Research. 2022.
  22. Ma L, Wang J, Ge JL, Wang Y, Zhang W, Du YN, Luo J, Li YP, Wang F, Fan GP, Chen R, Yao B, Zhao Z, Guo ML, Kim WK, Chai Y, Chen JF. (2021) Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus. EMBO Rep. 2021.
  23. Du J, Jing J, Chen S, Yuan Y, Feng J, Ho T-V, Sehgal P, Xu J, Jiang X, Chai Y.(2021) Arid1a regulates cell cycle exit of transit-amplifying cells through inhibiting the Aurka-Cdk1 axis in mouse incisor.  Development 2021: dev.198838 doi: 10.1242/dev.198838
  24. Du J, Jing J, Yuan Y, Feng J, Han X, Chen S, Li X, Peng W, Xu J, Ho T-V, Jiang X, Chai Y. 2021.
    Arid1a-Plagl1-Hh Signaling Is Indispensable for Differentiation-associated Cell Cycle Arrest of Tooth Root Progenitors. Cell Reports 35(1): 108007. doi: 10.1016/j.celrep.2021.108964.
  25. Johnson ZM, Yuan Y, Li X, Jashashvili T, Jamieson M, Urata M, Chen Y, Chai Y. 2021. Mesenchymal stem cells and 3D-osteoconductive scaffold regenerate calvarial bone in critical size defects in swine. Stem Cells Translational Medicine. 2021 April 1. doi: 10.1002/sctm.20-0534. PubMed PMID: 33794062. 
  26. Han X, Feng J, Guo T, Loh YE, Yuan Y, Ho TV, Cho C, Li J, Jing J, Janeckova E, He J, Pei F, Bi J, Song B, Chai Y (2021) Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. eLife. 2021 Jan 22; 10:e62387. doi: 10.7554/eLife.62387. PMID: 33482080.
  27. He J, Jing J, Feng J, Han X, Yuan Y, Guo T, Pei F, Ma Y, Cho C, Ho TV, Chai Y (2021) Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning. PLoS Genetics. 2021 Feb 17;17(2):31009320. doi: 10.1371/journal.pgen.1009320. PMID: 33596195
  28. Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. (2021) Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis. Cell. 2021 Jan 7; 184 (1) doi: 10.1016/j.cell/2020.11.037
  29. Jing J, Feng J, Li J, Zhao H, Ho T, He J, Yuan Y, Guo T, Du J, Urata M, Sharpe P, Chai Y. (2020) Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis. eLife 2021;10:e59459. doi: 10.7554/eLife.59459
  30. Ma Y, Jing J, Feng J, Yuan Y, Wen Q, Han X, He J, Chen S, Ho T, Chai Y. (2021) Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during root development. Development 2021 148: dev196360. doi: 10.1242/dev.196360
  31. Yuan Y, Loh YE, Han X, Feng J, Ho TV, He J, Jing J, Groff K, Wu A, and Chai Y. (2020) Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Science Advances. 2020 Dec 16; 6 (51): doi: DOI: 10.1126/sciadv.abb0119
  32. Men Y, Wang Y, Yi Y, Jing D, Luo W, Chai Y, Ge WP, Shen B, Stenberg W, Feng JQ, Zhao H. (2020) Gli1+ periodontium stem cells are regulated by osteocytes and occlusal force. Dev Cell. 2020 Sep 14;54(5):639-654.e6. doi:10.1016/j.devcel.2020.06.006. Epub 2020 Jul 10. PMID: 32652075.
  33.  Li X, Shan W, Yang Y, Joralmon D, Zhu Y, Chen Y, Yuan Y, Xu H, Rong J, Dai R, Nian Q, Chai Y, Chen Y. (2020) Limpet Tooth-Inspired Painless Microneedles Fabricated by Magnetic Field-Assisted 3D Printing. Adv. Funct. Mater. doi: 10.1002/adfm.202003725
  34. Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y. (2020) FaceBase 3: Analytical Tools and FAIR Resources for Craniofacial and Dental Research. Development 147: dev191213. doi: 10.1242/dev.191213
  35. Chen S, Jing J, Yuan Y, Feng J, Han X, Wen Q, Ho TV, Lee C, Chai Y.(2020) Runx2+ niche cells maintain mesenchymal tissue homeostasis through IGF signaling. Cell Reports 32(6): 108007. doi: 10.1016/j.celrep.2020.108007
  36. Wen Q, Jing J, Han X, Feng J, Yuan Y, Ma Y, Chen S, Ho T-V, Chai Y.(2020) Runx2 regulates mouse tooth root development via activation of WNT inhibitor Notum. Journal of Bone and Mineral Research, 35(11):2252-2264. doi: 10.1002/jbmr.4120
  37. Jackson-Weaver O, Ungvijanpunya N, Yuan Y, Qian J, Gou Y, Wu J, Shen H, Chen Y, Li M, Richard S, Chai Y, Sucov HM, Xu J. (2020) PRMT1-p53 Pathway Controls Epicardial EMT and Invasion. Cell Rep. 2020 Jun 9;31(10):107739. doi: 10.1016/j.celrep.2020.107739. PMID: 32521264; PMCID: PMC7425665.
  38. Zhang W, Ma L, Yang M, Shao Q, Xu J, Lu Z, Zhao Z, Chen R, Chai Y, Chen JF. (2020) Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes Dev. 2020 Feb 27. doi: 10.1101/gad.332494.119. [Epub ahead of print] PubMed PMID: 32115408.
  39. Li X, Yuan Y, Liu L, Leung YS, Chen Y, Guo Y, Chai Y, Chen Y. (2019) 3d printing of hydroxyapatite/tricalcium phosphate scaffold with hierarchical porous structure for bone regeneration. Bio-Design & Manufacturing 3: 15-29. doi: 10.1007/s42242-019-00056-5
  40. Zhang C, Lin J, Nguyen NY, Guo Y, Xu C, Seo C, Villafana E, Jimenez H, Chai Y, Guan R, Liu H. (2019) Antimicrobial Bioresorbable Mg-Zn-Ca Alloy for Bone Repair in a Comparison Study with Mg-Zn-Sr Alloy and Pure Mg. ACS Biomaterials Science & Engineering 6(1): 517-538. doi: 10.1021/acsbiomaterials.9b00903. 
  41. Janečková E, Feng J, Li J, Rodriguez G, Chai Y. (2019) Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development. PLOS ONE 14(10):e0223879. doi: 10.1371/journal.pone.0223879. PMCID PMC6793855
  42. Jing J, Feng J, Li J, Han X, He J, Ho TV, Du J, Urata MM, Chai Y. (2019) Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars eLife 2019 Jul 1; 8. e46426. doi: 10.7554/eLife.46426. PMCID: PMC6602580.
  43. Shi C, Yuan Y, Guo Y, Jing J, Ho TV, Han X, Li J, Feng J, Chai Y. (2019) BMP signaling in regulating mesenchymal stem cells in incisor homeostasis. Journal of Dental Research 98(8) 904-911. doi: 10.1177/0022034519850812. PMCID PMC6616121
  44. Li J, Rodriguez G, Han X, Janečková E, Kahng S, Song B, Chai Y. (2019) Regulatory mechanisms of soft palate development and malformations. Journal of Dental Research 98(9): 959-967. doi: 10.1177/0022034519851786. PMCID: PMC6651766.
  45. Yuan Y & Chai Y. (2019) Regulatory mechanisms of jaw bone and tooth development. Curr Top Dev Biol 133:91-118. doi: 10.1016/bs.ctdb.2018.12.013
  46. Youssef A Kousa, Huiping Zhu, Walid D Fakhouri, Yunping Lei, Akira Kinoshita, Raeuf R Roushangar, Nicole K Patel, A J Agopian, Wei Yang, Elizabeth J Leslie, Tamara D Busch, Tamer A Mansour, Xiao Li, Arianna L Smith, Edward B Li, Dhruv B Sharma, Trevor J Williams, Yang Chai, Brad A Amendt, Eric C Liao, Laura E Mitchell, Alexander G Bassuk, Simon Gregory, Allison Ashley-Koch, Gary M Shaw, Richard H Finnell, Brian C Schutte (2019) The TFAP2A–IRF6–GRHL3 genetic pathway is conserved in neurulation. Human Molecular Genetics, ddz010, doi: 10.1093/hmg/ddz010
  47. Guo Y, Yuan Y, Wu L, Ho TV, Jing J, Sugii H, Li J, Han X, Feng J, Guo C, Chai Y. (2018) BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair. Bone Research, 6, 1-13. PMCID: PMC6193039.
  48. Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y. (2018) Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Developmental Biology, 441(1), 191-203. PMCID: PMC6152919.
  49. Bobarnac Dogaru, G., Juneja, S.C., Shokrani, A., Hui, R., Chai, Y., and Pepper, JP (2018) The role of Hedgehog-responsive fibroblasts in facial nerve regeneration. Experimental Neurology, 303, 72-79. PMID: 29337143.
  50. Zhang, T., Ungvilanpunya, N., Jackson-Weaver-O., Guo, Y., Feng, J., Ho, T, Shen, Y., Liu, J., Richard, S., Jin., J., Hajishengallis, G., Chai, Y., and Xu, J (2018) Smad6 methylation represses NFκB activation and periodontal inflammation. JDR, 97, 810-819. PMID: 29420098.
  51. Giannobile, W. V., Chai, Y., Chen, Y., Healy, Klein, O., Lane, N., Longaker, M., Lotz, J., Mooney, D.J., Sfeir, C., Urata, M., Wagner, W., Wu, B., and Kohn, D. (2018) Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care. JDR, 97, 361-363.PMCID: PMC5863875.
  52. Guo, Y., Li, J., Jackson-Weaver, O., Wu, J., Gupta, R., Ho, T., Chen, Y., Li, M., Richard, S., Wang, J., Chai, Y., and Xu, J (2018) Protein arginine methyltransferase PRMT1 is essential for palatogenesis. JDR, 97, 1510-1518. PMID: 29986157.
  53. An, Z., Akily, B., Sabalic, M., Zong, G., Chai, Y., and Sharpe, P. (2018) Regulation of mesenchymal stem to transit-amplifying cell transition in the continuously growing mouse incisor. Cell Report, 23, 3102-3111.
  54. Sugii H, Grimaldi A, Li J, Parada C, Ho T-V, Feng J, Jing J, Yuan Y, Guo Y, Maeda H, and Chai Y. (2017) Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development. Development 144: 4037-4045. doi: 10.1242/dev.155176
  55. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y. (2017) BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development 144: 2560-2569. doi: 10.1242/dev.150136
  56. Tian H, Feng J, Li J, Ho TV, Yuan Y, Liu Y, Brindopke F, Figueiredo JC, Magee W III, Sanchez-Lara PA, Chai Y. (2017) Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Human Molecular Genetics 26(5): 860-872.
  57. Li J, Parada C, Harunaga J, and Chai Y. (2017) Cellular and molecular mechanisms of tooth root development. Development 144: 374-384. doi: 10.1242/dev.137216
  58. Sun Z, Yu W, Navarro MS, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. (2016) Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development 143: 4115-4126. doi:10.1242/dev.138883
  59. Park S, Zhao H, Urata M, Chai Y. (2016) Sutures possess strong regenerative capacity for calvarial bone injury. Stem Cells and Development 25: 1801-1807. PubMed PMID: 27762665.
  60. Feng J, Jing J, Sanchez-Lara PA, Bootwalla MS, Buckley J, Wu N, Yan Y, Chai Y. (2016) Generation and characterization of tamoxifen-inducible Pax9-CreER Knock-In Mice using CrispR/Cas9. Genesis. 2016 Jul 6. doi: 10.1002/dvg.22956. [Epub ahead of print] PubMed PMID: 27381449.
  61. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J; FaceBase Consortium, Chai Y. (2016) The FaceBase Consortium: A Comprehensive Resource for Craniofacial Researchers. Development. 2016 Jun 10. pii: dev.135434. [Epub ahead of print] PubMed PMID: 27287806.
  62. Burg ML, Chai Y, Yao CA, Magee W 3rd, Figueiredo JC. (2016)Epidemiology, Etiology, and Treatment of Isolated Cleft Palate.Front Physiol. 2016 Mar 1;7:67. doi: 10.3389/fphys.2016.00067. eCollection 2016. Review. PubMed PMID: 26973535; PubMed Central PMCID: PMC4771933.
  63. Grimaldi A, Parada C, Chai Y. (2015) A Comprehensive Study of Soft Palate Development in Mice. PLoS One. 2015 Dec 15;10(12):e0145018. doi:10.1371/journal.pone.0145018. eCollection 2015. PubMed PMID: 26671681; PubMed Central PMCID: PMC4687642.
  64. Parada C, Chai Y. (2015) Mandible and Tongue Development.Curr Top Dev Biol.2015;115:31-58. doi: 10.1016/bs.ctdb.2015.07.023. Epub 2015 Oct 1. PubMed PMID:26589920; PubMed Central PMCID: PMC4869709.
  65. Parada C, Han D, Grimaldi A, Sarrión P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y. (2015) Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 1;142(21):3734-45. doi:10.1242/dev.125328. Epub 2015 Sep 22. PubMed PMID: 26395480; PubMed Central PMCID: PMC4647211.
  66. Zhao H, Chai Y. (2015) Stem Cells in Teeth and Craniofacial Bones. J Dent Res. 2015 Nov;94(11):1495-501. doi: 10.1177/0022034515603972. Epub 2015 Sep 8. Review. PubMed PMID: 26350960; PubMed Central PMCID: PMC4622324.
  67. Liu Y, Feng JF, Li JY, Zhao Hu, Ho TV, Chai Y. (2015) An Nfic-Hedgehog Signaling Cascade Regulates Tooth Root Development. Development. 2015 Oct 1;142(19):3374-82. doi:10.1242/dev.127068. Epub 2015 Aug 20. PubMed PMID: 26293299; PubMed Central PMCID: PMC4631759.
  68. Li J, Feng J, Liu Y, Ho TV, Grimes W, Ho HA, Park S, Wang SL, Chai Y. (2015) BMP-SHH Signaling Network Controls Epithelial Stem Cell Fate via Regulation of Its Niche in the Developing Tooth. Dev Cell. 2015 Apr 20;33(2):125-35. doi:10.1016/j.devcel.2015.02.021. Epub 2015 Apr 9. PubMed PMID: 25865348; PubMed Central PMCID: PMC4406846.
  69. Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. (2015) The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr;17(4):386-96. doi: 10.1038/ncb3139. Epub 2015 Mar 23. PubMed PMID: 25799059; PubMed Central PMCID: PMC4380556.
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