New publication: Cerebral organoid & mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes

Zhang W, Ma L, Yang M, Shao Q, Xu J, Lu Z, Zhao Z, Chen R, Chai Y, Chen JF. (2020) Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes Dev. 2020 Feb 27. doi: 10.1101/gad.332494.119. [Epub ahead of print] PubMed PMID: 32115408.

Two new publications in the Journal of Dental Research

Shi C, Yuan Y, Guo Y, Jing J, Ho TV, Han X, Li J, Feng J, Chai Y. (2019) BMP signaling in regulating mesenchymal stem cells in incisor homeostasisJournal of Dental Research, in press.

Li J, Rodriguez G, Han X, Janečková E, Kahng S, Song B, Chai Y. (2019) Regulatory mechanisms of soft palate development and malformationsJournal of Dental Research, in press.

 

New publication: The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation

Youssef A Kousa, Huiping Zhu, Walid D Fakhouri, Yunping Lei, Akira Kinoshita, Raeuf R Roushangar, Nicole K Patel, A J Agopian, Wei Yang, Elizabeth J Leslie, Tamara D Busch, Tamer A Mansour, Xiao Li, Arianna L Smith, Edward B Li, Dhruv B Sharma, Trevor J Williams, Yang Chai, Brad A Amendt, Eric C Liao, Laura E Mitchell, Alexander G Bassuk, Simon Gregory, Allison Ashley-Koch, Gary M Shaw, Richard H Finnell, Brian C Schutte (2019) The TFAP2A–IRF6–GRHL3 genetic pathway is conserved in neurulation. Human Molecular Genetics, doi: 10.1093/hmg/ddz010