Category: Publications

1. Jing J, Feng J, Yuan Y, Guo T, Lei J, Pei F, Ho TV, Chai Y. (2022) Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat. Commun. 13, 4803 (2022). https://doi.org/10.1038/s41467-022-32490-y.

1. Jing J, Feng J, Yuan Y, Guo T, Lei J, Pei F, Ho TV, Chai Y. (2022)Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat. Commun. Accept.

1. Gu, R., Zhang, S., Saha, S.K., Ji, Y., Reynolds, K., McMahon, M., Sun, B., Islam, M., Trainor, P., Chen, Y., Xu, Y., Chai, Y., Burkart-Waco, D., and Zhou, C. (2022) Single-cell transcriptomics and gene-regulatory networks modulated by Wntless in mammalian midline facial formation and clefts. Development. 15 July 2022; 149 (14): dev200533. doi:10.1242/dev.200533.
2. Schuler, R. E., Bugacov, A., Hacia, J. G., Ho, T. V., Iwata, J., Pearlman, L., Samuels, B. D., Williams, C., Zhao, Z., Kesselman, C., & Chai, Y. (2022). FaceBase: A Community-Driven Hub for Data-Intensive Research. Journal of Dental Research. doi:10.1177/00220345221107905.

1. Stanton E, Urata M, Chen JF, Chai Y.(2022) The clinical manifestations, molecular mechanisms, and treatment of craniosynostosis. Dis Model Mech. 2022 Apr 1;15(4):dmm049390. doi: 10.1242/dmm.049390. Epub 2022 Apr 22. PMID: 35451466; PMCID: PMC9044212.
2. Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho T-V, Xu J, Chai Y. (2022) KDM6B interacts with TFDP1 to activate P53 signalling in regulating mouse palatogenesis. eLife. 2022 Feb 25;11:e74595. doi: 10.7554/eLife.74595. PMID: 35212626; PMCID: PMC9007587.

Ting MC, Farmer DJ, Teng CS, He J, Chai Y, Crump G, Maxson RE. (2021) Embryonic requirements for Tcf12 in the development of the mouse coronal suture. Development. Accepted.

Lei J, Chen S, Jing J, Guo T, Feng J, Ho TV, Chai Y. (2021) Inhibiting Hh signaling in Gli1+ osteogenic progenitors alleviates TMJOA. Journal of Dental Research (accepted)

Du J, Jing J, Chen S, Yuan Y, Feng J, Ho T-V, Sehgal P, Xu J, Jiang X, Chai Y.(2021) Arid1a regulates cell cycle exit of transit-amplifying cells through inhibiting the Aurka-Cdk1 axis in mouse incisor. Development 2021: dev.198838 doi: 10.1242/dev.198838 

1. Du J, Jing J, Yuan Y, Feng J, Han X, Chen S, Li X, Peng W, Xu J, Ho T-V, Jiang X, Chai Y.(2021)
   Arid1a-Plagl1-Hh Signaling Is Indispensable for Differentiation-associated Cell Cycle Arrest of Tooth Root Progenitors.
   Cell Reports 35(1): 108007. doi: 10.1016/j.celrep.2021.108964.

^{Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. (2021) Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis. Cell. 2021 Jan 7; 184 (1): doi: https://doi.org/10.1016/j.cell.2020.11.037}

Publication Highlights

• • Twist1 ^+/− craniosynostosis mice exhibit elevated ICP and cognitive deficits

  • Suture MSCs and resorbable biomaterials can support regeneration of patent suture

• Suture regeneration normalizes Twist1 ^+/− ICP, skull shape, and cognitive function

• Suture regeneration offers a biological solution for craniosynostosis patients

Jing J, Feng J, Li J, Zhao H, Ho T, He J, Yuan Y, Guo T, Du J, Urata M, Sharpe P, Chai Y. (2020) Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis. eLife, Accepted.