New Publication: Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis

Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. (2021) Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis. Cell. 2021 Jan 7; 184 (1): doi: https://doi.org/10.1016/j.cell.2020.11.037

Yu et al., develop a platform for cranial suture regeneration using a biodegradable material combined with mesenchymal stem cells in a mouse model of craniosynostosis that reverses increased intracranial pressure, skull and neurocognitive abnormalities.

Publication Highlights

    • Twist1 +/− craniosynostosis mice exhibit elevated ICP and cognitive deficits

    • Suture MSCs and resorbable biomaterials can support regeneration of patent suture

  • Suture regeneration normalizes Twist1 +/− ICP, skull shape, and cognitive function

  • Suture regeneration offers a biological solution for craniosynostosis patients